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Intracranial Subarachnoidal Route of Infection for Investigating Roles of Streptococcus suis Biofilms in Meningitis in a Mouse Infection Model
Published on: July 1, 2018
Streptococcus suis Meningitis: Epidemiology, Clinical Presentation and Treatment
Maria Hlebowicz1, Paweł Jakubowski1, Tomasz Smiatacz1
1Department of Infectious Diseases, Medical University of Gdansk, Gdansk, Poland.
Abstract:
Streptococcus suis, a prevalent porcine pathogen, may sporadically cause infections in humans, and has recently emerged as a cause of zoonoses in some professionals. The aim of this article was to review available data on epidemiology, etiopathogenesis, diagnostics, and management of the most common form of S. suis infection, purulent meningitis. Literature data show that S. suis is an important etiological factor of purulent meningitis, especially in subjects being occupationally exposed to contact with pigs and/or pork meat. Owing to growing incidence of S. suis meningitis, a history of such exposure should be verified in each patient presenting with typical meningeal symptoms. Whenever S. suis was confirmed as the etiological factor of purulent meningitis, therapeutic protocol should be adjusted appropriately, to avoid patient's exposure to potentially ototoxic antimicrobial agents and corticosteroids. Considering the biphasic character of S. suis meningitis and its frequently atypical outcome, all individuals with this condition should be optimally supervised by a multidisciplinary team, including an ENT specialist.
Insights
Streptococcus suis (S. suis) causes purulent meningitis, particularly in those with occupational pig exposure. Early verification of exposure and adjusted treatment are crucial for managing this zoonotic disease.
Area of Science:
- Zoonotic Diseases
- Infectious Diseases
- Microbiology
Background:
- Streptococcus suis (S. suis) is a common swine pathogen with emerging zoonotic potential.
- S. suis infections in humans, particularly purulent meningitis, are increasingly recognized.
- Occupational exposure to pigs and pork products is a significant risk factor.
Purpose of the Study:
- To review current data on the epidemiology, pathogenesis, diagnosis, and management of S. suis meningitis.
- To highlight the importance of S. suis as a cause of purulent meningitis in at-risk populations.
- To guide clinical practice for optimal patient outcomes.
Main Methods:
- Comprehensive literature review of S. suis meningitis.
- Analysis of epidemiological data, clinical presentations, and treatment strategies.
- Synthesis of information on diagnostic approaches and management protocols.
Main Results:
- S. suis is a significant cause of bacterial meningitis, especially in individuals with occupational exposure to swine.
- Typical meningeal symptoms warrant investigation into potential S. suis infection and relevant exposure history.
- Treatment requires careful consideration of antimicrobial agents and corticosteroids to prevent ototoxicity and manage biphasic disease characteristics.
Conclusions:
- Prompt identification of S. suis meningitis is critical, particularly in high-risk groups.
- Therapeutic protocols must be individualized to avoid adverse effects and manage the disease's complexity.
- Multidisciplinary team supervision, including ENT specialists, is recommended for optimal patient care due to potential atypical outcomes.
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