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Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
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Increase in Enterovirus D68 Infections in Young Children, United Kingdom, 2006-2016

Everlyn Kamau, Heli Harvala, Soile Blomqvist

    Emerging Infectious Diseases
    |March 12, 2019
    PubMed

    Insights

    Enterovirus D68 (EV-D68) seroprevalence increased in the UK from 2006-2016. Infections primarily affected young children, with higher incidence noted in 2016, coinciding with its emergence as a cause of severe respiratory illness.

    Area of Science:

    • Virology
    • Epidemiology
    • Public Health

    Background:

    • Enterovirus D68 (EV-D68) emerged as a significant pathogen causing severe respiratory illness and neurological complications, including paralysis.
    • Understanding the epidemiological trends of EV-D68 infection is crucial for public health preparedness.

    Purpose of the Study:

    • To determine the change in seroprevalence of EV-D68 in the United Kingdom.
    • To analyze age-stratified cohorts from 2006 to 2016, covering the emergence period of EV-D68 as a severe respiratory disease.
    • To assess the primary age groups affected by EV-D68 infections.

    Main Methods:

    • Analysis of age-stratified seroprevalence data for EV-D68.
    • Longitudinal study design covering the period 2006–2016 in the United Kingdom.
    • Comparison of infection incidence across different age groups and years.

    Main Results:

    • Significant changes in EV-D68 seroprevalence were observed between 2006 and 2016.
    • Infections were predominantly acquired by infants and young children.
    • A markedly higher incidence of EV-D68 infection was recorded in 2016 compared to previous years.

    Conclusions:

    • EV-D68 seroprevalence increased in the UK during the study period.
    • Young children represent the primary demographic for EV-D68 acquisition.
    • The findings highlight the growing impact of EV-D68 on pediatric respiratory health and the need for continued surveillance.

    Keywords:
    PicornaviridaeUnited Kingdomenterovirusepidemiologyneutralizationrespiratory infectionseroprevalenceviruses

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