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Platelet Serotonin Signaling in Patients With Cardiovascular Disease and Comorbid Depression

Marlene S Williams1, Roy C Ziegelstein, Una D McCann

  • 1From the Johns Hopkins University School of Medicine, Baltimore, MD.

Psychosomatic Medicine
|March 12, 2019
PubMed

Insights

Depression in cardiovascular patients increases cardiac event risk. While platelet serotonin response didn't differ, higher serotonin receptor density was observed in depressed patients, suggesting a potential link to adverse cardiac events.

Area of Science:

  • Cardiology
  • Psychiatry
  • Neuroscience

Background:

  • Depression in cardiovascular disease (CVD) patients correlates with poor clinical outcomes.
  • Biobehavioral mechanisms, particularly platelet serotonin signaling, are explored as explanations for this increased risk.

Purpose of the Study:

  • To investigate platelet serotonin signaling in patients with coronary artery disease (CAD) and depression.
  • To define the relationship between platelet serotonin signaling and cardiovascular complications in this cohort.

Main Methods:

  • 300 CAD patients (145 acute coronary syndrome, 155 stable CAD) were enrolled.
  • Depression assessed via Structured Clinical Interview for DSM-IV and Beck Depression Inventory II.
  • Platelet serotonin response measured by aggregation, activation, receptor density, and uptake; outcomes tracked for 12 months.

Main Results:

  • 13.6% had major depressive disorder; one-third had minimal depressive symptoms.
  • Depressed patients showed significantly higher incidence of major and minor adverse cardiac events.
  • Higher serotonin receptor density found in patients with major depressive disorder, particularly in ACS patients.

Conclusions:

  • Depressed cardiovascular patients exhibit higher serotonin receptor density and increased adverse cardiac events.
  • Findings suggest a potential link between platelet serotonin signaling alterations and cardiovascular complications in depressed patients.
  • Further research with larger samples and severe depression is warranted to validate these hypothesis-generating results.
Abstract

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