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Updated: Jan 28, 2026
Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
Published on: July 19, 2019
All-cause hospitalizations in multiple sclerosis patients
Introduction:
There is poor knowledge on current hospitalizations in the multiple sclerosis (MS) population. The purpose of this study was to determine hospitalization causes and outcomes in a MS hospital-based cohort.
Patients And Methods:
A retrospective chart review was performed on all patients admitted at our centre between August, 2009 and July, 2015, excluding those with no previous established diagnosis.
Results:
308 hospitalizations were included, representing a total of 155 patients (female, 67.5%). Median age at hospitalizations was 47 years, with median disease duration of 12 years. The most common overall reason for hospitalization was infectious diseases (22.1%), followed by MS relapses (12.7%) and neurogenic bladder (11%). The median length of hospitalization for all patients was 5 days and the progressive subtype of MS had longer lengths of hospitalization than the relapsing-remitting MS. Intensive care unit admission occurred in 23 cases (7.5%) and were associated with increased mortality and length of hospitalization. Of the 308 hospitalizations, 9 (2.9%) resulted in death.
Conclusion:
Infections are the most common cause of hospitalizations in our study, although MS relapses or complications related to MS continue to be significant causes of morbidity. Almost 8% of all MS hospitalizations required intensive care unit admission and these were related to longer admission lengths and higher death rates.
Insights
Infections are the leading cause of hospitalizations in multiple sclerosis (MS) patients, though MS relapses also contribute significantly. Intensive care unit admissions in MS patients are linked to longer hospital stays and increased mortality.
Area of Science:
- Neurology
- Clinical Medicine
- Epidemiology
Background:
- Limited understanding of current hospitalization patterns in the multiple sclerosis (MS) population.
- Need for data on causes and outcomes of MS patient hospitalizations.
Purpose of the Study:
- To investigate the primary reasons for hospitalization among patients with multiple sclerosis.
- To analyze the outcomes of hospitalizations within a hospital-based MS cohort.
Main Methods:
- Retrospective chart review of MS patients admitted between August 2009 and July 2015.
- Inclusion criteria: patients with a pre-existing diagnosis of multiple sclerosis.
Main Results:
- 308 hospitalizations from 155 MS patients were analyzed.
- Infectious diseases (22.1%) were the most frequent cause, followed by MS relapses (12.7%) and neurogenic bladder (11%).
- Intensive care unit admission (7.5%) correlated with higher mortality and longer hospital stays.
Conclusions:
- Infections are the primary driver of hospitalizations in this MS cohort.
- MS relapses and complications remain significant causes of morbidity.
- A notable percentage of MS hospitalizations require ICU care, associated with adverse outcomes.
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