Related Experiment Video
Updated: Jan 28, 2026

Endoscopic Ultrasound-Guided Biliary Drainage: Endoscopic Ultrasound-Guided Hepaticogastrostomy in Malignant Biliary Obstruction
Published on: March 25, 2022
Sublingual microcirculation in pancreatico-biliary surgery: An observational study
Mustafa Suker1, M Sherezade Tovar Doncel2, Alexandre A Pinto Lima3
1Department of Surgery, Erasmus MC University Medical Centre, Rotterdam, The Netherlands.
Changes in perfused vessels density (PVD) and proportion of perfused vessels (PPV) in the first 24 hours after surgery can predict a complicated perioperative course in patients undergoing pancreatico-biliary surgery.
Area of Science:
- Surgical oncology
- Critical care medicine
- Vascular biology
Background:
- Sublingual microcirculation assessment is explored for goal-directed fluid therapy.
- Observational cohort study design employed.
Purpose of the Study:
- Identify sublingual microcirculation parameters for goal-directed fluid therapy.
- Correlate microcirculatory changes with perioperative complications.
Main Methods:
- 16 patients undergoing elective pancreatico-biliary surgery included.
- Sublingual microcirculation measured pre-surgery (T0), early post-op (T1), and day 4 (T2).
- Parameters: MFI, TVD, PVD, and PPV.
Main Results:
- Significant differences in PVD small vessels (PVDs) and PPV small vessels (PPVs) between T0 and T1 in complicated vs. uncomplicated patients.
- Delta PVDs: -0.1 vs -8.2 (p=0.01); Delta PPVs: 7.0% vs -15.5% (p=0.01).
Conclusions:
- Changes in PVD and PPV are significant predictors of perioperative complications.
- A decrease in PVD and PPV within 24 hours post-surgery indicates a high risk of complications.
Related Concept Videos
Observational Studies
There are three types of observational studies – Prospective, retrospective, and cross-sectional.
Prospective Study
Prospective studies, also known as longitudinal or cohort studies, are carried out by collecting future data from groups sharing similar characteristics. One...
Naturalistic Observations
Actor-Observer Effect
Observational Learning
Data Collection by Observations
An astronomer viewing the motion and brightness of stars in the sky and recording the data is an example of observational data collection. A botanist recording...
Case Studies

