The related factors of sleep benefit in Parkinson's disease: A systematic review and meta-analysis
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Updated: Jul 1, 2026

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
Published on: July 24, 2019
Zhong Rui1, Chen Qingling2, Zhang Xinyue1
1Department of Neurology, The First Hospital of Jilin University, Chang Chun, Ji Lin Provence, China.
Background:
Sleep benefit (SB) refers to the poorly understood phenomenon in Parkinson's disease (PD) in which patients wake up in the morning with improved motor function. Although previous studies have suggested that several related factors are associated with SB, this relationship remains controversial.
Objective:
This systematic review and meta-analysis aimed to identify the possible related factors of SB in PD.
Methods:
We searched PubMed, EMBASE and WanFang databases to collect eligible articles. We calculated pooled estimates of odds ratios (ORs) or the mean deviation (MD) with 95% confidence intervals.
Results:
We found 3 related factors associated with SB: the duration of PD (MD 1.22, 95% CI: 0.21-2.23), sleep efficiency (MD -4.48,95% CI: -7.24- -2.44), and on-state MDS-UPDRS-Ⅲ total score (MD 3.05, 95% CI: 0.53-5.57).
Conclusion:
PD patients with SB are more likely to have a long duration of PD, a low sleep efficiency and a high MDS-UPDRS-Ⅲ total score. Our work helps obtain a better understanding of sleep SB in PD and its underlying mechanisms. More studies need to be conducted to evaluate the associations between clinical factors in PD and the SB phenomenon.
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