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Updated: Jan 28, 2026
A Piglet Model of Neonatal Hypoxic-Ischemic Encephalopathy
Published on: May 16, 2015
[The effect of controllable moderate hypothermia on hemostasis in newborns with hypoxemic ischemic encephalopathy.]
E S Philippov1, M V Gomellya1,2, A A Zarubin1,3
1The Federal state budget educational institution of higher education "The Irkutsk state medical university" of Minzdrav of Russia, 664003, Irkutsk, Russia.
The Purpose:
To study effect of controllable moderate hypothermia on system of hemostasis in newborns with hypoxemic ischemic encephalopathy.
Materials And Methods:
The retrospective analysis was carried out concerning 38 medical records of newborns with acute hypoxia of fetus (group I), 12 medical records of newborns with acute hypoxia of fetus against the background of chronic hypoxia of fetus (group II), 20 healthy newborns (group III) and 20 healthy adults. The thromboelastography was implemented in three stages: at first, third and sixth days of life of newborns.
Conclusion:
The thromboelastography is to be implemented in newborns with hypoxemic ischemic encephalopathy due to occurrence of of hemostasis shifting to hypocoagulation and high risk of bleeding. In healthy full-term children a physiological hypercoagulation was established as compared with adults without alterations of processes of lysis of clots. In newborns with chronic hypoxia of fetus against the background of applied medical hypothermia, in comparison with healthy newborns, decreasing of number of thrombocytes are observed and possibly lower functional activity of thrombocytes up to third day and also lower activity of plasma component of hemostasis at retained elasticity and strength of developed clots. The sixth day, after heating, the system of hemostasis is normalized and number of thrombocytes is restored. In newborns, having acute hypoxia of fetus against the background of chronic hypoxia of fetus higher risk of bleeding is noted at minimal difference according results of thromboelastography.
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