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Related Experiment Videos

CBP/p300 in brain development and plasticity: disentangling the KAT's cradle.

Michal Lipinski1, Beatriz Del Blanco1, Angel Barco1

  • 1Instituto de Neurociencias (Universidad Miguel Hernández - Consejo Superior de Investigaciones Científicas), Av. Santiago Ramón y Cajal s/n, Sant Joan d'Alacant, 03550, Alicante, Spain.

Current Opinion in Neurobiology
|March 12, 2019
PubMed
Summary

CBP and p300 (KAT3A/KAT3B) are crucial transcriptional co-activators involved in nervous system development and neuronal plasticity. This review explores their complex roles, functions, and interactions in neurons.

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Epigenetics

Background:

  • CBP (KAT3A) and p300 (KAT3B) are paralogous transcriptional co-activators.
  • They possess a lysine acetyltransferase (KAT) domain and multiple protein-binding domains.
  • These proteins interact with numerous partners and modify thousands of lysine residues.

Purpose of the Study:

  • To review the critical roles of KAT3 proteins in nervous system development.
  • To discuss their function and mode of action in postmitotic neurons.
  • To explore their regulation of stimuli-driven transcription and neuronal plasticity.

Main Methods:

  • Literature review of existing research on CBP and p300.
  • Integration of recent findings on KAT3 protein functions.

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  • Analysis of molecular interactions and substrate specificities.

    • Main Results:

    • CBP and p300 play essential roles in neurodevelopment.
    • They regulate transcription and plasticity in mature neurons.
    • Their complex network of interactions and substrates highlights functional redundancy and specificity.

    Conclusions:

    • The KAT3 proteins (CBP and p300) are central regulators in neuronal function and development.
    • Understanding their intricate molecular relationships is key to deciphering neuronal processes.
    • Further research is needed to fully elucidate their diverse roles in the nervous system.