Related Experiment Video
Updated: Jan 28, 2026

Formulating and Characterizing an Exosome-based Dopamine Carrier System
Published on: April 4, 2022
Targeted release mechanism of λ-cyhalothrin nanocapsules using dopamine-conjugated silica as carrier materials
Wenbing Zhang1, Gang Tang1, Hongqiang Dong1
1College of Plant Protection, China Agricultural University, Beijing, China.
Abstract:
Based on the specific binding between the receptors and ligands, novel targeted nanocapsules were prepared by using silica covalently bonded with dopamine to increase the insecticidal efficacy of λ-cyhalothrin. The targeted release mechanism of λ-cyhalothrin nanocapsules (NC) nanocapsules was verified by enzymatic analysis, fluorescent marking method and high performance liquid chromatograph. The results showed NC had uniform particle size (800 nm) and approximately 31% (w/w) loading efficiency of λ-cyhalothrin. The stability of λ-cyhalothrin in nanocapsuels was improved under different pH and temperature conditions. The NC showed sustainable release properties and the release kinetics mainly belonged to Fickian diffusion at all experimental conditions. Compared to λ-cyhalothrin emulsifiable concentrate and microcapsule suspension, the NC exhibited more excellent insecticidal activity. The micronucleus test indicated that NC significantly reduced the genotoxicity of λ-cyhalothrin to non-target organisms. This work offers a novel and efficient way to use targeted drug delivery system to improve the insecticidal activity, and may be extended to other pesticides in the future.
Related Concept Videos
Mechanism of Conjugation
Electron Carriers
Over the many stages of cellular respiration, glucose breaks down into carbon dioxide and water. Electron carriers pick up electrons lost by glucose in these reactions, temporarily storing and releasing them into the electron...
Drug Absorption Mechanism: Carrier-Mediated Membrane Transport
Facilitated diffusion is a passive process that utilizes human Solute Carrier (SLC) transporters. These transporters bind to the drug, undergo structural...
Conjugated Proteins
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
Conjugated Proteins
Energy-releasing Steps of Glycolysis
The first energy-releasing step—the 6th step of glycolysis...

