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Organotypic Tissue Model Systems for Investigating Host-Pathogen Interactions In Vitro
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Multi-Omics Strategies Uncover Host-Pathogen Interactions.

Mohd M Khan1,2, Orna Ernst1, Nathan P Manes1

  • 1Laboratory of Immune System Biology (LISB), National Institute of Allergy and Infectious Diseases , National Institutes of Health (NIH) , 9000 Rockville Pike , Bethesda , Maryland 20814 , United States.

ACS Infectious Diseases
|March 13, 2019
PubMed
Summary
This summary is machine-generated.

Systems biology and multi-omics approaches reveal molecular mechanisms of host-pathogen interactions. Understanding these complex interactions is crucial for developing strategies against microbial infections and immune responses.

Keywords:
Gram-negative bacteriahost−pathogen interactionslipopolysaccharidemass spectrometrymulti-omics

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Area of Science:

  • Systems biology
  • Immunology
  • Genomics
  • Microbiology

Background:

  • The Human Genome Project spurred large-scale systemic projects, advancing systems biology.
  • Systems biology has illuminated Gram-negative bacterial recognition, host signal transduction, and immune tolerance.
  • Understanding infection progression requires deeper insights into host-pathogen molecular mechanisms.

Purpose of the Study:

  • To discuss how multi-omics analyses enhance understanding of host-pathogen interactions.
  • To explore the molecular basis of maladaptive immune responses to microbes.
  • To highlight the importance of integrative multi-omics data for studying infections.

Main Methods:

  • Integrative multi-omics experiments acquiring and analyzing multimodal data.
  • Modeling of complex biological data from host-pathogen interactions.
  • Focus on genetic, immunologic, transcriptional, translational, and metabolic mechanisms.

Main Results:

  • Multi-omics analyses are crucial for dissecting host-pathogen molecular interactions.
  • These approaches reveal mechanisms underlying immune tolerance and maladaptive responses.
  • Data integration is key to understanding infection dynamics from microbial entry to clearance.

Conclusions:

  • Multi-omics are essential for unraveling the complexities of host-pathogen interactions.
  • Further research using these methods will advance our knowledge of infectious diseases.
  • Understanding molecular mechanisms aids in addressing microbial threats and immune dysregulation.