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Updated: Jan 28, 2026
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Isolation and Characterization of the Murine Uterosacral Ligaments and Pelvic Floor Organs
Published on: March 3, 2023
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Pelvic floor dysfunction in midlife women
1a Department of Obstetrics and Gynaecology , Queen's University , Kingston , ON , Canada.
Summary
Midlife estrogen loss impacts women's pelvic floor health, causing urinary incontinence and prolapse. Understanding genitourinary atrophy is key for evaluating pelvic function and quality of life.
Area of Science:
- Women's Health
- Gynecology
- Urology
Background:
- Pelvic floor dysfunction (PFD) in women encompasses urinary incontinence and pelvic organ prolapse.
- Genitourinary atrophy is frequently linked to PFD in midlife women.
- Pelvic floor tissues are hormonally responsive and affected by estrogen decline.
Purpose of the Study:
- To review the effects of menopause and aging on female pelvic floor function.
- To discuss how estrogen deprivation contributes to structural and functional pelvic floor failure.
- To present an evaluation framework for pelvic function in midlife women.
Main Methods:
- Literature review of menopause, aging, and pelvic floor disorders.
- Analysis of estrogen's role in pelvic floor tissue integrity.
- Framework development for clinical assessment.
Main Results:
- Menopause and aging lead to genitourinary atrophy and PFD.
- Estrogen loss causes structural and functional changes in pelvic tissues.
- Quality of life is significantly impacted by incontinence, prolapse, and atrophy.
Conclusions:
- Estrogen deficiency is a primary driver of PFD in midlife women.
- Comprehensive evaluation of PFD should include quality of life assessment.
- Early intervention strategies may mitigate PFD progression.
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