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Related Experiment Videos

Do asthmatics suffer bronchoconstriction during rapid eye movement sleep?

C M Shapiro, J R Catterall, I Montgomery

    British Medical Journal (Clinical Research Ed.)
    |May 3, 1986
    PubMed
    Summary

    Asthma patients experiencing nocturnal wheeze may find relief by understanding its link to sleep. This study found that bronchoconstriction, or airway narrowing, is significantly worse during rapid eye movement (REM) sleep.

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    Area of Science:

    • Pulmonary Medicine
    • Sleep Science
    • Respiratory Physiology

    Background:

    • Nocturnal wheeze is a common and troubling symptom for asthma patients.
    • The precise cause of nocturnal asthma exacerbations remains unclear, but sleep is implicated.
    • Understanding the relationship between sleep stages and asthma symptoms is crucial for effective management.

    Purpose of the Study:

    • To investigate the relationship between nocturnal bronchoconstriction in asthma patients and specific sleep stages.
    • To determine if airway narrowing during sleep is linked to rapid eye movement (REM) or non-REM sleep.

    Main Methods:

    • Eight asthma patients with nocturnal wheeze and eight controls underwent forced expiratory maneuvers upon waking.
    • Wakings were timed to distinguish between temporal effects and sleep stage-related phenomena (REM vs. non-REM sleep).

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  • Multivariate analysis was used to differentiate temporal effects from sleep stage effects on lung function.

    • Main Results:

    • Asthma patients exhibited significant overnight bronchoconstriction, with peak expiratory flow rate decreasing substantially.
    • Lung function (forced expiratory volume in one second and peak expiratory flow rate) was significantly lower after waking from REM sleep compared to non-REM sleep.
    • Bronchoconstriction was found to be significantly related to both time of night and REM sleep.

    Conclusions:

    • Asthma patients experience significant bronchoconstriction during the night.
    • Bronchoconstriction is more pronounced during rapid eye movement (REM) sleep in asthma patients.
    • This suggests that REM sleep plays a critical role in nocturnal asthma exacerbations.