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Updated: Jan 28, 2026
08:23
Design and Development of Aptamer–Gold Nanoparticle Based Colorimetric Assays for In-the-field Applications
Published on: June 23, 2016
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Simple and rapid detection of bisphenol A using a gold nanoparticle-based colorimetric aptasensor
Eun-Hee Lee1, Sung Ku Lee2, Min Jung Kim3
1Department of Environmental Science and Engineering, Ewha Womans University, Seoul, Republic of Korea.
Food Chemistry
|March 13, 2019
Summary
A new colorimetric aptasensor detects bisphenol A (BPA) using gold nanoparticles and aptamers. This simple test offers rapid, visual detection of BPA in food and environmental samples at very low levels.
Area of Science:
- Nanotechnology
- Analytical Chemistry
- Environmental Science
Background:
- Bisphenol A (BPA) is an endocrine-disrupting chemical with widespread environmental contamination.
- Sensitive and rapid detection methods for BPA are crucial for monitoring food and environmental safety.
Purpose of the Study:
- To develop a simple, rapid, and visual colorimetric aptasensor for the detection of bisphenol A (BPA).
Main Methods:
- Development of a colorimetric aptasensor using colloidal gold nanoparticles (AuNPs) conjugated with BPA-specific aptamers.
- Utilized electrolyte-induced aggregation of AuNP-aptamer conjugates in the presence of BPA.
- Observed color change (red to blue) due to surface plasmon resonance shift upon aggregation.
Main Results:
- The aptasensor achieved a visual limit of detection for BPA as low as 1 pg/mL.
- Demonstrated selective detection of BPA over various structural analogs.
- Successfully detected BPA in a single grain of rice, validating its practical applicability.
Conclusions:
- The developed colorimetric aptasensor provides a simple, rapid, and sensitive method for BPA detection.
- Suitable for screening food and environmental samples for BPA contamination at sub-ppb levels.
- Offers a promising tool for public health and environmental monitoring efforts.
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