Related Experiment Video
Updated: Jan 28, 2026

A Pipette-Tip Based Method for Seeding Cells to Droplet Microfluidic Platforms
Published on: February 11, 2019
Hydrophobic paper-based SERS platform for direct-droplet quantitative determination of melamine
Chenmeng Zhang1, Tingting You1, Nan Yang1
1Key Laboratory of Bio-inspired Smart Interfacial Science and Technology of Ministry of Education, School of Chemistry, Beihang University, Beijing 100191, China.
Abstract:
A novel hydrophobic-SERS substrate platform based on silver nanoparticles (AgNPs) functionalized commercially available filter paper was reported. Compared with conventional substrates, not only could this novel SERS substrate meet the requirements of simple and large-scale preparation, but also realized direct droplet-detection with reusable property. In this work, the fabrication, physical characterization, and SERS sensitivity of the substrates to spot-on food determination were studied. The experimental results show the method exhibited high reproducibility with less than 9% spot-to-spot variation in Raman intensity. Furthermore, the method was successfully applied to detect melamine in diluted milk with the instrument detection limit (IDL) down to 1 ppm in a linear correlation (1 ppm-1000 ppm). In addition, this SERS substrate could also be applied successfully in other fields, such as the determination of pesticide (thiram) and dye (malachite green) in real environment.
Related Concept Videos
Transmission-based Precautions I: Contact, Enteric, and Droplets
Contact Precautions:
Contact precautions are the measures taken to prevent the transmission of infectious agents, especially epidemiologically important microorganisms such as MRSA or influenza, primarily transmitted through direct or indirect contact with an...
Determining Order of Reaction
Crossed Aldol Reaction Using Strong Bases: Directed Aldol Reaction
Directing Effect of Substituents: meta-Directing Groups
Determining the pH of Salt Solutions
Directing Effect of Substituents: ortho–para-Directing Groups

