Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

423
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
423
Synaptic Signaling01:12

Synaptic Signaling

79.3K
Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
79.3K
Plasticizers01:31

Plasticizers

362
Water-reducers, or plasticizers, are chemical admixtures used in concrete to improve strength and workability. These additives reduce the water-cement ratio without compromising workability, lower the cement content while maintaining the same workability, or increase workability to assist concrete placement in inaccessible areas.
Plasticizers function by using surface-active agents to create repulsive electrostatic forces between cement particles. This dispersion enhances the concrete's...
362
Plasticity00:58

Plasticity

3.1K
Plasticity is the property where an object loses its elasticity and undergoes irreversible deformation, even after the deformation forces are eliminated. If a material deforms irreversibly without increasing stress or load, then this is called ideal plasticity. For example, when a force is applied to an aluminum rod, it changes its shape, but it does not return to its original shape once the force is removed. Plastic deformation or ductility is thus a permanent deformation or change in the...
3.1K
Deleterious Substances in Aggregate01:25

Deleterious Substances in Aggregate

536
Deleterious substances in aggregates can be detrimental to the quality and durability of concrete. These substances include organic impurities like loam, which interfere with cement hydration and are usually present in the sand. These prevent a good bond between aggregate and cement paste. Organic impurities can be detected using the colorimetric test, where the darkness of a solution after agitation indicates the level of organic content.
Another type of impurity is clay and fine material that...
536
Plastic Behavior01:21

Plastic Behavior

560
A material's elastic behavior is characterized by the disappearance of stress once the load is removed, allowing the material to return to its original state. However, when stress surpasses the yield point, yielding commences, marking the onset of plastic deformation or permanent set. This change from elastic to plastic behavior is influenced by the peak stress value and the duration before the load is removed. An intriguing observation occurs when a specimen is loaded, unloaded, and...
560

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Is there a halo-enzymopathy in Parkinson's disease?

Neurologia·2022
Same author

Microorganisms associated with increased risk of Parkinson's disease.

Neurologia·2022
Same author

Endocannabinoid-mediated synaptic plasticity and substance use disorders.

Neurologia·2021
Same author

Microorganisms that are related with increased risk for Parkinson's disease.

Neurologia·2020
Same author

Is there a halo-enzymopathy in Parkinson's disease?

Neurologia·2019
Same author

Mice lacking the peroxisome proliferator-activated receptor α gene present reduced number of dopamine neurons in the substantia nigra without altering motor behavior or dopamine neuron decline over life.

Neuroscience·2011

Related Experiment Video

Updated: Jan 28, 2026

3D Modeling of Dendritic Spines with Synaptic Plasticity
07:13

3D Modeling of Dendritic Spines with Synaptic Plasticity

Published on: May 18, 2020

7.4K

Endocannabinoid-mediated synaptic plasticity and substance use disorders.

E Fernández-Espejo1, L Núñez-Domínguez2

  • 1Departamento de Fisiología Médica y Biofísica, Facultad de Medicina, Universidad de Sevilla, Sevilla, España.

Neurologia
|March 13, 2019
PubMed
Summary
This summary is machine-generated.

Substance use disorders disrupt brain reward circuits and addictive behaviors by altering endocannabinoid-mediated synaptic plasticity. This disruption impacts both short-term and long-term neuroplasticity, contributing to addiction development.

Keywords:
AddictionAdicciónDependenceDependenciaDrogaDrug of abuseEndocannabinoidEndocannabinoideNeuroplasticidadNeuroplasticity

More Related Videos

Identification of Orexin and Endocannabinoid Receptors in Adult Zebrafish Using Immunoperoxidase and Immunofluorescence Methods
08:37

Identification of Orexin and Endocannabinoid Receptors in Adult Zebrafish Using Immunoperoxidase and Immunofluorescence Methods

Published on: June 25, 2019

8.4K
Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
14:27

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

13.4K

Related Experiment Videos

Last Updated: Jan 28, 2026

3D Modeling of Dendritic Spines with Synaptic Plasticity
07:13

3D Modeling of Dendritic Spines with Synaptic Plasticity

Published on: May 18, 2020

7.4K
Identification of Orexin and Endocannabinoid Receptors in Adult Zebrafish Using Immunoperoxidase and Immunofluorescence Methods
08:37

Identification of Orexin and Endocannabinoid Receptors in Adult Zebrafish Using Immunoperoxidase and Immunofluorescence Methods

Published on: June 25, 2019

8.4K
Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
14:27

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

13.4K

Area of Science:

  • Neuroscience
  • Addiction Research
  • Molecular Biology

Background:

  • Drugs of abuse target brain reward circuits, leading to substance use disorders.
  • Endocannabinoids (e.g., anandamide, 2-arachidonyl-glycerol) are key mediators of synaptic plasticity in these circuits.
  • Disruption of endocannabinoid signaling is implicated in the development of addictive behaviors.

Purpose of the Study:

  • To investigate the role of endocannabinoids in synaptic plasticity alterations associated with substance use disorders.
  • To elucidate how drug abuse disrupts endocannabinoid-mediated neuroplasticity.
  • To understand the contribution of endocannabinoid system dysfunction to addictive behaviors.

Main Methods:

  • Review of existing literature on endocannabinoids and synaptic plasticity in addiction.
  • Analysis of short-term plasticity mechanisms (e.g., suppression of inhibition/excitation).
  • Examination of long-term plasticity (LTP/LTD) and drug-induced changes.

Main Results:

  • Substance use disorders are characterized by disrupted endocannabinoid-mediated synaptic plasticity.
  • Endocannabinoids regulate both short-term (e.g., disinhibition) and long-term (LTP/LTD) neuroplasticity.
  • Drug abuse alters endocannabinoid activity, affecting processes like hypofrontality and sensitization.

Conclusions:

  • Alterations in endocannabinoid activity play a significant role in the synaptic plasticity disruptions underlying addiction.
  • Dysfunctional endocannabinoid signaling contributes to abnormal brain changes and the development of substance use disorders.
  • Targeting the endocannabinoid system may offer therapeutic strategies for addiction treatment.