Related Experiment Video

Updated: Jan 28, 2026

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
07:25

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia

Published on: September 22, 2020

3.8K

Association between stress hormones and perioperative risk in patients with critical limb ischemia undergoing

Yoshimitsu Soga1, Mitsuyoshi Takahara2, Osamu Iida3

  • 1Department of Cardiology, Kokura Memorial Hospital, Kitakyushu, Japan.

Journal of Vascular Surgery
|March 13, 2019
PubMed

Insights

High levels of stress hormones like epinephrine and cortisol are linked to increased risk of major adverse cardiovascular events (pMACE) in critical limb ischemia (CLI) patients after revascularization. These hormones also correlate with higher 30-day mortality.

Area of Science:

  • Cardiovascular Medicine
  • Endocrinology
  • Vascular Surgery

Background:

  • Critical limb ischemia (CLI) is associated with poor clinical outcomes.
  • The impact of stress hormones on CLI patient outcomes after revascularization is not well understood.
  • Perioperative major adverse cardiovascular events (pMACE) are a significant concern in CLI patients.

Purpose of the Study:

  • To investigate the association between stress hormone levels and the risk of pMACE in CLI patients undergoing revascularization.
  • To determine if specific stress hormones predict adverse cardiovascular events in this population.
  • To explore the relationship between stress hormones and short-term mortality following revascularization.

Main Methods:

  • Analysis of 467 CLI patients with pre-revascularization stress hormone levels (epinephrine, norepinephrine, dopamine, cortisol).
  • Primary endpoint: pMACE (all-cause mortality, myocardial infarction, stroke) within 30 days.
  • Propensity score matching employed to mitigate confounding factors.

Main Results:

  • pMACE occurred in 4.5% of patients.
  • Elevated epinephrine, dopamine, and cortisol levels were observed in patients with pMACE.
  • Post-matching analysis revealed significantly higher epinephrine and cortisol levels in the pMACE group.
  • Multivariate analysis confirmed independent associations of epinephrine and cortisol with pMACE risk.

Conclusions:

  • Stress hormones, specifically epinephrine and cortisol, are significantly associated with pMACE risk in CLI patients undergoing revascularization.
  • Both epinephrine and cortisol levels predict 30-day mortality after revascularization in CLI patients.
  • These findings highlight the potential role of stress hormone monitoring in risk stratification for CLI patients.
Abstract

Keywords:
CortisolCritical limb ischemiaDopamineEpinephrineRevascularization

More Related Videos

Therapy Interventions for Upper Limb Amputees Undergoing Selective Nerve Transfers07:59

Therapy Interventions for Upper Limb Amputees Undergoing Selective Nerve Transfers

Published on: October 29, 2021

4.1K
Preclinical Model of Hind Limb Ischemia in Diabetic Rabbits07:34

Preclinical Model of Hind Limb Ischemia in Diabetic Rabbits

Published on: June 2, 2019

10.3K

Related Concept Videos

Types of Hormones02:13

Types of Hormones

Hormones can be classified into three main types based on their chemical structures: steroids, peptides, and amines. Their actions are mediated by the specific receptors they bind to on target cells.
83.3K
Types of Hormones01:21

Types of Hormones

Hormones are classified into four main groups: steroids, eicosanoids, amino acid-based derivatives, and peptide hormones.
Steroids and eicosanoids fall under the category of lipid-soluble hormones. Steroids are derived from cholesterol and feature four interconnected carbon rings with variable side chains. Notable examples include estradiol from ovaries and testosterone from testes, exemplifying the critical roles of these lipid-soluble hormones in reproductive physiology. Eicosanoids, derived...
7.0K
Hormonal Regulation01:33

Hormonal Regulation

The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
36.0K
Hormonal Regulation01:40

Hormonal Regulation

Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
48.0K
Plant Hormones01:56

Plant Hormones

Plant hormones—or phytohormones—are chemical molecules that modulate one or more physiological processes of a plant. In animals, hormones are often produced in specific glands and circulated via the circulatory system. However, plants lack hormone-producing glands.
27.5K
Responses to Salt Stress02:02

Responses to Salt Stress

Salt stress—which can be triggered by high salt concentrations in a plant’s environment—can significantly affect plant growth and crop production by influencing photosynthesis and the absorption of water and nutrients.
14.5K