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Modeling Spontaneous Metastatic Renal Cell Carcinoma mRCC in Mice Following Nephrectomy
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Immunotherapy Is Changing First-Line Treatment of Metastatic Renal-Cell Carcinoma

Matthew K Labriola1, Kristen A Batich1, Jason Zhu1

  • 1Division of Medical Oncology, Department of Medicine, Duke Cancer Institute, Durham, NC.

Clinical Genitourinary Cancer
|March 13, 2019
PubMed

Insights

Metastatic renal-cell carcinoma (mRCC) treatment is evolving. Combination therapies, including immunotherapy and targeted agents, are improving outcomes for advanced mRCC patients.

Area of Science:

  • Oncology
  • Immunology

Background:

  • Increasing incidence of renal-cell carcinoma, with a third diagnosed at advanced stages.
  • Limitations of traditional therapies like VEGF and tyrosine kinase inhibitors for metastatic renal-cell carcinoma (mRCC).

Purpose of the Study:

  • To review advances and controversies in first-line mRCC treatment.
  • To explore the role of tumor-immune expression profiles in predicting treatment outcomes.
  • To discuss the future of combination anti-VEGF and immunotherapy platforms.

Main Methods:

  • Review of recent literature on mRCC treatment modalities.
  • Analysis of the evolving landscape of targeted therapies and immunotherapies.
  • Examination of immuno-oncology and tumor immunoreactivity in mRCC.

Main Results:

  • Immunotherapy checkpoint inhibitors have significantly impacted first-line treatment for intermediate to poor risk mRCC.
  • Combination immunotherapy and immunotherapy with targeted agents show promise in altering disease outcomes.
  • A deeper understanding of tumor immunoreactivity is driving the evolution of combination therapy.

Conclusions:

  • Combination therapy is emerging as a primary treatment modality for mRCC.
  • Future treatment strategies will likely involve combined anti-VEGF and immunotherapeutic approaches.
  • Personalized treatment based on tumor-immune profiles is crucial for improving mRCC patient outcomes.
Keywords:
Immune checkpoint inhibitorsMetastatic renal-cell carciomaTargeted therapiesVEGF therapiesVEGF-immunotherapy combinations

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