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Published on: November 21, 2013
An Approach to the Pharmacotherapy of Neuroleptic Malignant Syndrome
Roland van Rensburg1, Eric H Decloedt1
1Van Rensburg, MBChB Dip HIV Man(SA), Division of Clinical Pharmacology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa. Decloedt, MBChB BSc(Hons) FCCP(SA) MMed(Clin Pharm), Division of Clinical Pharmacology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Abstract:
Neuroleptic malignant syndrome is a rare, idiosyncratic emergency associated with exposure to dopamine antagonists, commonly antipsychotic drugs. The typical clinical picture consists of altered consciousness, muscular rigidity, fever, and autonomic instability. While the condition has generally been well described, the pathophysiology is still poorly understood. The importance of this case report is to highlight the lack of robust evidence-based treatment for this emergency. We submit an approach to the pharmacotherapy of neuroleptic malignant syndrome based on the available evidence.
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