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New indications for topical ivermectin 1% cream: a case series study
Wioletta Barańska-Rybak1, Elżbieta Kowalska-Olędzka2
1Department of Dermatology, Venereology and Allergology, Medical University of Gdansk, Gdansk, Poland.
Postepy Dermatologii I Alergologii
|March 13, 2019
Summary
Topical ivermectin cream effectively treated mild to moderate perioral dermatitis, seborrheic dermatitis, and acne vulgaris. The treatment showed significant reduction in inflammatory lesions with minimal side effects.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Topical ivermectin is recognized for treating inflammatory papulopustular rosacea.
- Its anti-inflammatory properties suggest potential benefits for other facial dermatoses.
Purpose of the Study:
- To evaluate the efficacy of topical ivermectin 1% cream.
- Assessed treatment for mild to moderate perioral dermatitis (PD), seborrheic dermatitis (SD), and acne vulgaris (AV).
Main Methods:
- A study involving 20 patients (8 PD, 8 SD, 4 AV) conducted from November 2016 to July 2017.
- Efficacy was measured using Investigator Global Assessment (IGA) and Patient Global Assessment (PGA) scores.
Main Results:
- All patients demonstrated positive responses with reduced inflammatory lesions.
- Complete or near-complete clearance (IGA score 0-1) was achieved in all 20 patients.
- Adverse events were mild and transient, including desquamation and stinging in two PD patients.
Conclusions:
- Topical ivermectin is well-tolerated and effective for treating mild to moderate PD, SD, and AV.
- The study supports ivermectin's benefit in managing these common facial dermatoses.
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