Related Experiment Video
Updated: Jan 28, 2026

Treating Low Back Pain in Failed Back Surgery Patients with Multicolumn-lead Spinal Cord Stimulation
Published on: June 26, 2018
Why Did COAPT Win While MITRA-FR Failed? Defining the Appropriate Patient Population for MitraClip
Kimberly Atianzar1,2, Ming Zhang2, Zachary Newhart2
1Medical College of Georgia at Augusta University Augusta, GA, US.
Abstract:
In 2018, the world of functional mitral regurgitation changed with the presentation of two trials - Multicentre Study of Percutaneous Mitral Valve Repair MitraClip Device in Patients With Severe Secondary Mitral Regurgitation (MITRA-FR) and Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients with Functional Mitral Regurgitation (COAPT). The trials, which seemed to point in two different directions, raised significant questions for the field. This article looks at the differences in effective regurgitant area, guideline-directed medical therapy, patient selection, technical clues and other reasons why the trials had similar aims but very different findings.
Related Concept Videos
Hypothesis: Accept or Fail to Reject?
There are two ways to indicate that the null hypothesis is not rejected. 'Accept' the null...
Conservation of Small Populations
What is Population Genetics?
Population Growth
What are Populations and Communities?
Defining Psychology

