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Hypocalcemia Revealing an Enteropathy-Associated T-cell Lymphoma
Maria Belen Alonso Ortiz1, Noel Lorenzo Villalba2, Emilio Almaraz Marroquin3
1Department of Internal Medicine, Gran Canaria University Hospital, Las Palmas, Spain.
Background:
Enteropathy-associated T-cell lymphoma (EATL) is a rare and aggressive type of extranodal T-cell lymphoma (TCL) arising in the gastrointestinal (GI) tract and represents 5-8% of all T-cell non-Hodgkin lymphomas (NHL) and 10-25% of primary intestinal lymphomas.
Case Presentation:
We reported a 78-year-old woman presenting with severe hypocalcemia. Investigations confirmed vitamin D and iron deficiency as well as hypoalbuminemia. Celiac disease was suspected and confirmed, but despite intravenous calcium and magnesium supplementation and a gluten-free diet, normal electrolyte levels were never reached. Intestinal perforation was the clue to the diagnosis of enteropathy-associated T-cell lymphoma (EATL).
Conclusion:
Hypocalcemia can result from multiple conditions. In patients not responding to adequate supplementation, further investigations should be performed to diagnose the underlying condition.
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