Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Integrins01:10

Integrins

5.4K
Animal and protozoan cells do not have cell walls to help maintain shape and provide structural stability. Instead, these eukaryotic cells secrete a sticky mass of carbohydrates and proteins into the spaces between adjacent cells. This network of proteins and molecules is called an extracellular matrix or ECM.
Some ECM proteins assemble into a basement membrane to which the remaining components adhere. Proteoglycans typically form the bulk of the ECM while fibrous proteins, like collagen,...
5.4K
Activation of Integrins01:15

Activation of Integrins

5.1K
Integrins bind ligands and transmit information from outside the cell to inside or vice-versa through an "outside-in signaling" or "inside-out signaling."
In "outside-in signaling," external factors in the extracellular space bind to exposed ligand binding sites on integrins. This causes the inactive protein to undergo a conformational change to become active. Integrins are often clustered on the cell membrane. Repetitive and regularly spaced ligand binding...
5.1K
Receptor-mediated Endocytosis01:39

Receptor-mediated Endocytosis

110.7K
Overview
110.7K
Nonsense-mediated mRNA Decay02:27

Nonsense-mediated mRNA Decay

11.8K
The Upf proteins that carry out nonsense-mediated decay (NMD) are found in all eukaryotic organisms, including humans. Each protein has an individual role, but they need to work in collaboration. Upf1 is an ATP-dependent RNA helicase that unwinds the RNA helix. Because Upf1 can unwind any RNA, Upf2 and Upf3 are required to help Upf1 discriminate between nonsense and normal mRNAs.
Usually, Upf3 binds to an Exon Junction Complex (EJC) at mRNA splice sites. If a ribosome fully translates the mRNA,...
11.8K
SN1 Reaction: Stereochemistry02:15

SN1 Reaction: Stereochemistry

10.3K
This lesson provides an in-depth discussion of the stereochemical outcomes in an SN1 reaction.
In the first step of an SN1 reaction, the bond between the electrophilic carbon and the leaving group ionizes to generate the carbocation intermediate. The second step of the mechanism is the nucleophilic attack.
In the formed carbocation, the positively charged carbon is sp2 hybridized with a trigonal planar geometry. As all the three substituents lie on the same plane, a plane of symmetry for the...
10.3K
SN1 Reaction: Kinetics02:05

SN1 Reaction: Kinetics

9.6K
In an SN2 reaction, the reaction rate depends on both the type of nucleophile and the substrate. A hindered tertiary alkyl halide is practically inert to the SN2 mechanism despite using a strong nucleophile.
However, Sir Christopher Ingold and Edward D. Hughes, who studied the kinetics of various nucleophilic substitution reactions, noticed that a tertiary alkyl halide does undergo a nucleophilic substitution reaction in the presence of a weak nucleophile. While studying the substitution...
9.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Novel Whole Gene Deletion of <i>BCKDHB</i> by Alu-Mediated Non-allelic Recombination in a Chinese Patient With Maple Syrup Urine Disease.

Frontiers in genetics·2018
Same author

Dkk3 dependent transcriptional regulation controls age related skeletal muscle atrophy.

Nature communications·2018
Same author

Tilianin-loaded Reactive Oxygen Species-Scavenging Nano-Micelles Protect H9c2 Cardiomyocyte Against Hypoxia/Reoxygenation-Induced Injury.

Journal of cardiovascular pharmacology·2018
Same author

Exploring Biogeochemistry and Microbial Diversity of Extant Microbialites in Mexico and Cuba.

Frontiers in microbiology·2018
Same author

Skeletal muscle regeneration is modulated by inflammation.

Journal of orthopaedic translation·2018
Same author

Fibrosarcoma arising in the paranasal sinus: a clinicopathological and radiological analysis.

Dento maxillo facial radiology·2018
Same journal

An exploratory analysis of disulfidptosis-related gene signatures in minimal change disease identifies metabolic and immune associations.

Frontiers in cell and developmental biology·2026
Same journal

Longitudinal changes in the phenotypic profile of circulating extracellular vesicles in healthy individuals.

Frontiers in cell and developmental biology·2026
Same journal

Mesenchymal stem cells in intrahepatic and extrahepatic biliary diseases: mechanisms and therapeutic applications.

Frontiers in cell and developmental biology·2026
Same journal

CD109 exhibits a dynamic expression pattern in coronary endothelium and endocardial-derived valve mesenchyme during heart development with preserved morphogenesis following endothelial-specific deletion.

Frontiers in cell and developmental biology·2026
Same journal

Significance of fatty acid metabolism regulators in the diagnosis and subtype classification in non-alcoholic fatty liver disease.

Frontiers in cell and developmental biology·2026
Same journal

Tumor suppressor network dysregulation in neuroblastoma: molecular mechanisms and precision therapeutic opportunities.

Frontiers in cell and developmental biology·2026
See all related articles

Related Experiment Video

Updated: Jan 28, 2026

Tension Gauge Tether Probes for Quantifying Growth Factor Mediated Integrin Mechanics and Adhesion
09:56

Tension Gauge Tether Probes for Quantifying Growth Factor Mediated Integrin Mechanics and Adhesion

Published on: February 11, 2022

3.1K

Thy-1 in Integrin Mediated Mechanotransduction.

Ping Hu1, Thomas H Barker1

  • 1Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, United States.

Frontiers in Cell and Developmental Biology
|March 13, 2019
PubMed
Summary
This summary is machine-generated.

Thy-1, a cell surface glycoprotein, acts as a mechanotransduction mediator. It translates extracellular mechanical cues into cellular responses through interactions with integrins, impacting various biological processes.

Keywords:
Thy-1cis interactionintegrinmechanotransductiontrans interaction

More Related Videos

Author Spotlight: Development of a Method for Identifying Small Molecular Antagonists of &#946;2 Integrin Activation
04:15

Author Spotlight: Development of a Method for Identifying Small Molecular Antagonists of β2 Integrin Activation

Published on: February 2, 2024

2.3K
Imaging Integrin Tension and Cellular Force at Submicron Resolution with an Integrative Tension Sensor
07:20

Imaging Integrin Tension and Cellular Force at Submicron Resolution with an Integrative Tension Sensor

Published on: April 25, 2019

8.0K

Related Experiment Videos

Last Updated: Jan 28, 2026

Tension Gauge Tether Probes for Quantifying Growth Factor Mediated Integrin Mechanics and Adhesion
09:56

Tension Gauge Tether Probes for Quantifying Growth Factor Mediated Integrin Mechanics and Adhesion

Published on: February 11, 2022

3.1K
Author Spotlight: Development of a Method for Identifying Small Molecular Antagonists of &#946;2 Integrin Activation
04:15

Author Spotlight: Development of a Method for Identifying Small Molecular Antagonists of β2 Integrin Activation

Published on: February 2, 2024

2.3K
Imaging Integrin Tension and Cellular Force at Submicron Resolution with an Integrative Tension Sensor
07:20

Imaging Integrin Tension and Cellular Force at Submicron Resolution with an Integrative Tension Sensor

Published on: April 25, 2019

8.0K

Area of Science:

  • Cell Biology
  • Biophysics

Background:

  • Glycosylphosphatidylinositol (GPI)-anchored glycoprotein Thy-1 is widely expressed on cell surfaces.
  • Thy-1 has diverse known functions including T cell activation, cell adhesion, and fibrogenesis.
  • Emerging evidence highlights Thy-1's role in mechanotransduction.

Purpose of the Study:

  • To review the role of Thy-1 in mechanotransduction.
  • To elucidate how Thy-1 translates extracellular mechanical cues into intracellular signaling pathways.

Main Methods:

  • Literature review focusing on Thy-1 and mechanotransduction.
  • Analysis of studies investigating Thy-1's interactions with integrins.

Main Results:

  • Thy-1 functions as a critical mediator of mechanotransduction.
  • Thy-1's mechanotransduction capability is dependent on both trans and cis interactions with RGD-binding integrins.

Conclusions:

  • Thy-1 plays a significant role in cellular responses to mechanical stimuli.
  • Understanding Thy-1-integrin interactions is key to deciphering its mechanotransduction functions.