Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Indicators02:39

Indicators

60.4K
Certain organic substances change color in dilute solution when the hydronium ion concentration reaches a particular value. For example, phenolphthalein is a colorless substance in any aqueous solution with a hydronium ion concentration greater than 5.0 × 10−9 M (pH < 8.3). In more basic solutions where the hydronium ion concentration is less than 5.0 × 10−9 M (pH > 8.3), it is red or pink. Substances such as phenolphthalein, which can be used to determine the pH of a solution, are...
60.4K
Predicting Reaction Outcomes02:24

Predicting Reaction Outcomes

10.8K
Kinetics describes the rate and path by which a reaction occurs. In contrast, thermodynamics deals with state functions and describes the properties, behavior, and components of a system. It is not concerned with the path taken by the process and cannot address the rate at which a reaction occurs. Although it does provide information about what can happen during a reaction process, it does not describe the detailed steps of what appears on an atomic or a molecular level. On the other hand,...
10.8K
Outcomes of Glycolysis01:13

Outcomes of Glycolysis

107.1K
Nearly all the energy used by cells comes from the bonds that make up complex organic compounds. These organic compounds are broken down into simpler molecules, such as glucose. As a result, cells extract energy from glucose over many chemical reactions—a process called cellular respiration.
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
107.1K
Guidelines for Writing Outcome01:11

Guidelines for Writing Outcome

3.8K
When developing expected outcomes for a patient care plan, the nurse should adhere to the following recommendations:
Patient outcomes reflect the patient's response to the goal rather than what the nurse aims to achieve. Terminology should be observable and measurable to avoid the reader's interpretation. The desired outcome should be realistic and achievable in the designated care timeframe. Expected outcomes should align with adjunctive therapies. The outcome should enhance care...
3.8K
What is an Experiment?01:12

What is an Experiment?

17.7K
An experiment is a planned activity carried out under controlled conditions. The purpose of an experiment is to investigate the relationship between two variables. When one variable causes change in another, we call the first variable the explanatory or independent variable. The affected variable is called the response or dependent variable. In a randomized experiment, the researcher manipulates values of the explanatory variable and measures the resulting changes in the response variable. The...
17.7K
Mechanical Ventilation I: Indication and Settings01:29

Mechanical Ventilation I: Indication and Settings

2.8K
Mechanical ventilation is a life-saving technique for managing acute respiratory failure and other respiratory complications. The process involves using a machine known as a ventilator to supply oxygen to the lungs and assist in removing carbon dioxide. It serves as a bridge to long-term mechanical ventilation or a temporary measure until ventilatory support is discontinued. The ventilator can maintain this function for a prolonged period, providing critical support for patients until they can...
2.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Annual report of national clinical database-breast cancer registry in 2023: systemic therapy for small breast cancer.

Breast cancer (Tokyo, Japan)·2026
Same author

Clinical Predictors and Long-term Outcomes of Non-benign Breast Phyllodes Tumors.

Cancer diagnosis & prognosis·2026
Same author

A Case of Prostate Cancer Recurrence Presenting With Lung Cancer-Like Computed Tomography Findings.

Respirology case reports·2026
Same author

Synchronous Bilateral Breast Invasive Ductal Carcinoma With Osteoclast-Like Stromal Giant Cells in a 44-Year-Old Woman: A Case Report.

Cureus·2026
Same author

Radiofrequency Ablation for Early Stage Breast Cancer as a Potential Alternative to Partial Mastectomy: 5-Year Results from the Multiple-Center, Single-Arm, Phase 3 RAFAELO Study (NCCH1409).

Annals of surgical oncology·2026
Same author

Emerging advances in non-surgical ablation for early-stage breast cancer.

Japanese journal of radiology·2026

Related Experiment Video

Updated: Jan 28, 2026

Improving Student Outcomes with an Adaptable Molecular Cloning Course-Based Undergraduate Research Experience
10:17

Improving Student Outcomes with an Adaptable Molecular Cloning Course-Based Undergraduate Research Experience

Published on: November 15, 2024

1.7K

RFA experiences, indications and clinical outcomes.

Takayuki Kinoshita1

  • 1National Cancer Center Hospital, Tokyo, Japan. takinosh@ncc.go.jp.

International Journal of Clinical Oncology
|March 13, 2019
PubMed
Summary

Radiofrequency ablation therapy (RFA) shows promise for early-stage breast cancer, achieving a 90% complete ablation rate in Phase I. Ongoing studies are evaluating its long-term safety, efficacy, and cosmetic benefits compared to standard treatments.

Keywords:
Multi-center studyNon-surgical ablationRadiofrequency ablation therapySmall breast carcinoma

More Related Videos

Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy
09:18

Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy

Published on: January 12, 2019

10.8K
Reliable Mechanochemistry: Protocols for Reproducible Outcomes of Neat and Liquid Assisted Ball-mill Grinding Experiments
13:05

Reliable Mechanochemistry: Protocols for Reproducible Outcomes of Neat and Liquid Assisted Ball-mill Grinding Experiments

Published on: January 23, 2018

11.2K

Related Experiment Videos

Last Updated: Jan 28, 2026

Improving Student Outcomes with an Adaptable Molecular Cloning Course-Based Undergraduate Research Experience
10:17

Improving Student Outcomes with an Adaptable Molecular Cloning Course-Based Undergraduate Research Experience

Published on: November 15, 2024

1.7K
Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy
09:18

Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy

Published on: January 12, 2019

10.8K
Reliable Mechanochemistry: Protocols for Reproducible Outcomes of Neat and Liquid Assisted Ball-mill Grinding Experiments
13:05

Reliable Mechanochemistry: Protocols for Reproducible Outcomes of Neat and Liquid Assisted Ball-mill Grinding Experiments

Published on: January 23, 2018

11.2K

Area of Science:

  • Oncology
  • Minimally Invasive Surgery
  • Medical Technology

Background:

  • Screening mammography increases early-stage breast cancer detection.
  • Radiofrequency ablation (RFA) is explored as a minimally invasive alternative to surgery.
  • Current evidence is insufficient to establish RFA as a standard breast cancer therapy.

Purpose of the Study:

  • To evaluate RFA as a standalone local therapy for early breast cancer.
  • To assess the long-term safety, efficacy, and cosmetic outcomes of RFA.
  • To demonstrate RFA's non-inferiority to breast-conserving surgery regarding recurrence rates.

Main Methods:

  • Phase I study: RFA treatment of localized tumors (≤2 cm) with histopathological confirmation.
  • Phase II study: Multicenter evaluation of RFA without resection.
  • Phase III study (RAFAELO): Non-inferiority trial comparing RFA to breast-conserving surgery, focusing on ipsilateral breast tumor recurrence (IBTR).

Main Results:

  • Phase I study achieved a 90% complete histopathological ablation rate.
  • Phase II and III studies are ongoing to gather long-term safety, efficacy, and cosmetic data.
  • The primary endpoint for Phase III is the IBTR rate, a key indicator of local tumor control.

Conclusions:

  • RFA demonstrates potential as an effective local treatment for early breast cancer.
  • Results from the ongoing RAFAELO multicenter study are crucial for standardizing RFA.
  • Further evidence is needed to support RFA as a standard therapy, with a focus on oncologic outcomes and patient-reported benefits.