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Gleason Score Correlation Between Prostate Needle Biopsy and Radical Prostatectomy Materials
Neşe Yeldir1, Esin Yildiz, Gökçe Dündar
1Department of Pathology, Cizre Dr. Selahattin Cizrelioğlu State Hospital, ŞIRNAK, TURKEY.
Turk Patoloji Dergisi
|March 13, 2019
Summary
Comparing prostate needle biopsy and prostatectomy results, this study found significant differences in Gleason score, tumor volume, and laterality. However, agreement improved with higher Gleason scores and larger tumor volumes, aiding prostate cancer prognosis.
Area of Science:
- Uropathology
- Oncology
- Surgical Pathology
Background:
- Prostate cancer is a leading cancer in men.
- The Gleason score is crucial for grading prostate cancer.
- International Society of Urological Pathology updates guide Gleason grading.
Purpose of the Study:
- To assess concordance of Gleason score, tumor volume, and laterality between prostate needle biopsy and prostatectomy.
- To evaluate the accuracy of biopsy in predicting final prostatectomy findings.
Main Methods:
- Analysis of biopsy and prostatectomy materials from 112 patients.
- Evaluation of Gleason grades using the updated system.
- Calculation of tumor volume and assessment of laterality (unilateral/bilateral).
Main Results:
- Statistically significant discordance was observed for Gleason score, tumor volume, and laterality.
- Concordance between biopsy and prostatectomy increased with higher Gleason scores.
- Concordance also improved as tumor volume increased.
Conclusions:
- Biopsy, digital rectal exam, and PSA levels are sensitive for prostate adenocarcinoma diagnosis.
- Gleason score, tumor volume, and localization are vital for patient management and prognosis.
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