Related Experiment Video

Updated: Jan 28, 2026

Activating Autophagy by Aerobic Exercise in Mice
08:44

Activating Autophagy by Aerobic Exercise in Mice

Published on: February 3, 2017

12.7K

Melatonin-mediated regulation of autophagy: Making sense of double-edged sword in cancer

Mohammad Mirza-Aghazadeh-Attari1,2, Amir Mohammadzadeh1,2, Ali Adib1,2

  • 1Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.

Journal of Cellular Physiology
|March 13, 2019
PubMed

Insights

Melatonin, a natural compound, influences autophagy, a cellular process crucial for stability. This study explores melatonin

Area of Science:

  • Oncology
  • Cellular Biology
  • Biochemistry

Background:

  • Extensive research targets reversing tumorigenesis and curing malignancies.
  • Melatonin, a naturally occurring compound, exhibits anticancer properties, offering potential for cancer prevention and treatment.
  • Autophagy, a cellular self-degradation process, is vital for maintaining cellular stability under stress and preventing early cell death.

Purpose of the Study:

  • To discuss the significance of melatonin and autophagy in cancer.
  • To investigate the effects of melatonin on autophagy.
  • To elucidate melatonin's role in the tumorigenesis process.

Main Methods:

  • Literature review on melatonin and autophagy.
  • Analysis of existing studies on melatonin's anticancer mechanisms.
  • Examination of the interplay between melatonin, autophagy, and tumorigenesis.

Main Results:

  • Melatonin demonstrates potential anticancer effects through various mechanisms.
  • Melatonin influences autophagy, a key cellular process involved in stress response and survival.
  • Understanding melatonin's modulation of autophagy provides insights into its role in preventing and treating cancer.

Conclusions:

  • Melatonin's interaction with autophagy is a critical factor in its anticancer activity.
  • Targeting melatonin and modulating autophagy may represent novel strategies for cancer therapy.
  • Further research into this relationship can advance cancer prevention and treatment modalities.
Keywords:
Beclin-1autophagycancer progressioncancer suppressionmelatonin

More Related Videos

Confocal Imaging of Double-Stranded RNA and Pattern Recognition Receptors in Negative-Sense RNA Virus Infection06:44

Confocal Imaging of Double-Stranded RNA and Pattern Recognition Receptors in Negative-Sense RNA Virus Infection

Published on: January 26, 2019

8.4K
A Primary Human Trophoblast Model to Study the Effect of Inflammation Associated with Maternal Obesity on Regulation of Autophagy in the Placenta11:44

A Primary Human Trophoblast Model to Study the Effect of Inflammation Associated with Maternal Obesity on Regulation of Autophagy in the Placenta

Published on: September 27, 2017

11.8K

Related Concept Videos

Gene Regulation in Microbial Communities: Quorum Sensing01:28

Gene Regulation in Microbial Communities: Quorum Sensing

Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
569
Autophagy01:27

Autophagy

Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
5.8K
The Sense of Self: Reflected Self-Appraisal and Social Comparison02:57

The Sense of Self: Reflected Self-Appraisal and Social Comparison

According to Charles Cooley, we base our image on what we think other people see (Cooley 1902). We imagine how we must appear to others, then react to this speculation. We don certain clothes, prepare our hair in a particular manner, wear makeup, use cologne, and the like—all with the notion that our presentation of ourselves is going to affect how others perceive us. We expect a certain reaction, and, if lucky, we get the one we desire and feel good about it. But more than that, Cooley...
55.9K
Regulated Protein Degradation02:58

Regulated Protein Degradation

It is vital to regulate the activity of enzymatic as well as non-enzymatic proteins inside the cell. This can be achieved either through creating a balance between their rate of synthesis and degradation or regulating the intrinsic activity of the protein. Both these regulation mechanisms play an essential role in the normal functioning of cells.
Protein degradation plays two important roles in the cells. It helps to protect cells from misfolded or damaged proteins before they lead to a...
8.8K
Fixing Double-strand Breaks02:04

Fixing Double-strand Breaks

The double-stranded structure of DNA has two major advantages. First, it serves as a safe repository of genetic information where one strand serves as the back-up in case the other strand is damaged. Second, the double-helical structure can be wrapped around proteins called histones to form nucleosomes, which can then be tightly wound to form chromosomes. This way, DNA chains up to 2 inches long can be contained within microscopic structures in a cell. A double-stranded break not only damages...
14.6K
Chromatin Structure Regulates pre-mRNA Processing02:41

Chromatin Structure Regulates pre-mRNA Processing

In eukaryotic cells, nascent mRNA transcripts need to undergo many post-transcriptional modifications to reach the cell cytoplasm and translate into functional proteins. For a long time, transcription and pre-mRNA processing were considered two independent events that occur sequentially in the cell. However, it has now been well established that transcription and pre-mRNA processing are two simultaneous processes that are precisely regulated inside the cell.
The chromatin structure, especially...
8.2K