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Antimüllerian Hormone Levels of Infants with Premature Thelarche

Nursel Muratoğlu Şahin1, Elvan Bayramoğlu1, Hatice Nursun Özcan2

  • 1Pediatric Health and Disease Training and Research Hospital, Dr. Sami Ulus Obstetrics and Gynecology, Clinic of Pediatric Endocrinology, Ankara, Turkey

Journal of Clinical Research in Pediatric Endocrinology
|March 13, 2019
PubMed

Insights

Infants with premature thelarche (PT) have lower Antimüllerian hormone (AMH) levels than healthy peers. This suggests AMH may suppress early pubertal changes, and low AMH could contribute to PT development.

Area of Science:

  • Pediatric Endocrinology
  • Reproductive Endocrinology
  • Biochemistry

Background:

  • Antimüllerian hormone (AMH) plays a role in pubertal development.
  • Mini puberty is characterized by higher AMH concentrations than the prepubertal period.
  • Premature thelarche (PT) is the early onset of breast development in infants.

Purpose of the Study:

  • To investigate Antimüllerian hormone (AMH) concentrations in infants diagnosed with premature thelarche (PT).
  • To compare AMH levels in infants with PT to a healthy control group.
  • To explore potential correlations between AMH, FSH, and pubertal markers in infants with PT.

Main Methods:

  • Studied 45 female infants with PT (1-3 years) and 37 healthy controls.
  • Evaluated bone age, pelvic ultrasonography, LH, FSH, estradiol, and AMH in the PT group.
  • Measured serum AMH concentrations in the control group.

Main Results:

  • Serum AMH concentrations were significantly lower in infants with PT (1.66 ng/mL) compared to controls (1.96 ng/mL).
  • A negative correlation was observed between AMH and FSH levels in infants with PT (r=-0.360, p=0.015).
  • No significant correlations were found between AMH and various uterine or ovarian parameters.

Conclusions:

  • This is the first study to report AMH levels in infants with premature thelarche.
  • Lower AMH levels in infants with PT, along with the negative AMH-FSH correlation, suggest AMH may inhibit early pubertal development.
  • Decreased AMH may be a contributing factor to the development of premature thelarche in infancy.
Abstract

Keywords:
AMHpremature thelarcheinfancymini-puberty

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