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Updated: Jan 27, 2026

Creating Two-Dimensional Patterned Substrates for Protein and Cell Confinement
Published on: September 6, 2011
Dynamics of proteins confined in non-ionic bicontinuous microemulsions: a FCS study
Oliver Wrede1, Sören Großkopf1, Thorsten Seidel2
1Physical and Biophysical Chemistry, Department of Chemistry, Bielefeld University, Bielefeld, Germany. thomas.hellweg@uni-bielefeld.de.
Abstract:
In our present work we present an approach which allows one to confine proteins in structurally nearly identical bicontinuous microemulsions with systematically decreasing water domain size. It is shown that sub-diffusive behaviour occurs already at water domain sizes below 13 nm. However, above 13 nm normal diffusion is seen. Moreover, we compare protein diffusion in microemulsions to the transport of a much smaller fluorescent dye.
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