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Functional Groups02:45

Functional Groups

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Functional groups are a group of atoms with characteristic properties, which when linked to the carbon skeleton of a molecule, alter the properties of that molecule. For example, the presence of certain functional groups on a molecule will make them hydrophilic, whereas others will make them hydrophobic. These functional groups are an indispensable part of organic chemistry and important components of biological molecules, such as carbohydrates, proteins, lipids, and nucleic acids. Each...
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Proteins perform many mechanical functions in a cell. These proteins can be classified into two general categories- proteins that generate mechanical forces and proteins that are subjected to mechanical forces. Proteins providing mechanical support to the structure of the cell, such as keratin, are subjected to mechanical force, whereas proteins involved in cell movement and transport of molecules across cell membranes, such as an ion pump, are examples of generating mechanical force. 
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Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
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Fabrication of Custom Agarose Wells for Cell Seeding and Tissue Ring Self-assembly Using 3D-Printed Molds
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3D Printing Enabled Customization of Functional Microgels.

Xuan Liu, Jie Tao, Jinlu Liu

  • 1Scientific Research Center , The Seventh Affiliated Hospital of Sun Yat-sen University , Shenzhen 518107 , Guangdong , P. R. China.

ACS Applied Materials & Interfaces
|March 13, 2019
PubMed
Summary
This summary is machine-generated.

This study introduces a rapid 3D printing method for creating customized injectable microgels. This digital light processing technique enables tailored microgels for cell therapy and drug delivery applications.

Keywords:
3D printingbiotherapydrug deliverymicrogelsnanoparticles

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Drug Delivery Systems

Background:

  • Injectable microgels are crucial for advanced cell therapy and drug delivery.
  • Current methods for fabricating customized microgels are often slow and expensive.

Purpose of the Study:

  • To develop a rapid and cost-effective method for fabricating customized microgels.
  • To demonstrate the utility of these microgels for incorporating drugs and cells.

Main Methods:

  • Utilized digital light processing (DLP) based 3D printing.
  • Employed photopolymerizable monomer solutions for microgel construction.
  • Incorporated nanoparticle-encapsulated drugs and live cells into the microgels.

Main Results:

  • Fabricated microgels with precise control over shape and size.
  • Achieved rapid microgel formation (within 2 seconds).
  • Demonstrated sustained drug release and viable cell encapsulation with proliferation.

Conclusions:

  • A novel 3D printing process for custom functional microgels was established.
  • The developed microgels show potential for therapeutic applications in drug delivery and cell therapy.
  • This method offers a scalable and versatile platform for advanced biomaterial fabrication.