Trichothecenes from a Soil-Derived Trichoderma brevicompactum
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Updated: Jan 27, 2026

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Published on: October 20, 2023
Saranyoo Klaiklay1, Vatcharin Rukachaisirikul2, Saowanit Saithong2
1Faculty of Science and Industrial Technology , Prince of Songkla University , Surat Thani Campus, Muang Surat Thani, Surat Thani 84000 , Thailand.
Abstract:
Six new (1-6), together with seven known (7-13), trichothecenes were isolated from the soil-derived Trichoderma brevicompactum PSU-RSPG27. Their structures were established using spectroscopic data. The structure of 1 was confirmed by X-ray data. Trichodermin (7) exhibited the most potent activity against Plasmodium falciparum (K1 strain) with an IC50 value of 0.1 μM, while other trichothecenes (1, 8, 9, and 12) were much less active, with IC50 values in the range of 7.1-9.6 μM. Compound 7 displayed activity against noncancerous Vero cells with an IC50 value of 0.4 μM. The remaining compounds showed moderate to weak activity, with IC50 values in the range of 6.9-15.3 μM. Compounds 7 and 12 were active against human oral carcinoma (KB) cells with IC50 values of 2.4 and 3.7 μM, respectively. Additionally, compounds 7 and 12 displayed antifungal activity against Candida albicans with the respective MIC values of 1 and 2 μg/mL and were active against Cryptococcus neoformans with equal MIC values of 4 μg/mL.
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