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Interaction between HFE and haptoglobin polymorphisms and its relation with plasma glutathione levels in obese

Laura Aguiar1, Cláudia Marinho2, Rute Martins3

  • 1Instituto de Investigação Científica Bento da Rocha Cabral, Lisbon, Portugal.

Cellular and Molecular Biology (Noisy-Le-Grand, France)
|March 13, 2019
PubMed

Insights

Childhood obesity is linked to oxidative stress. This study found that specific gene variants in haptoglobin and HFE are associated with lower antioxidant capacity in obese children, highlighting potential genetic factors in this public health issue.

Area of Science:

  • Pediatric Endocrinology
  • Nutritional Science
  • Genetics

Background:

  • Childhood obesity is a significant public health concern.
  • Obesity is associated with chronic inflammation and oxidative stress.
  • Genetic factors may influence antioxidant response in obese children.

Purpose of the Study:

  • To investigate the relationship between iron metabolism genes (HFE, haptoglobin) and antioxidant capacity in obese children.
  • To evaluate the role of haptoglobin phenotype and HFE gene polymorphism in oxidative stress markers.
  • To assess the antioxidant response capacity in childhood obesity.

Main Methods:

  • Recruitment of 118 obese children and 89 eutrophic children.
  • Analysis of plasmatic glutathione concentrations (tGSH, GSSG) as markers of oxidative stress.
  • Genotyping for HFE gene polymorphisms (H63D) and haptoglobin phenotypes.

Main Results:

  • Obese children exhibited significantly decreased total glutathione (tGSH) levels.
  • Reduced tGSH levels were significant only in obese children with the haptoglobin (Hp) 2 allele.
  • Obese children with Hp 2.2 phenotype and HFE H63D polymorphism showed lower tGSH/GSSG ratios, indicating impaired antioxidant status.

Conclusions:

  • Haptoglobin and HFE gene variants are associated with oxidative stress in childhood obesity.
  • Specific haptoglobin phenotypes and HFE polymorphisms may contribute to reduced antioxidant capacity in obese children.
  • These findings suggest a genetic component influencing oxidative stress in pediatric obesity.

Keywords:
Gene interaction.GlutathioneHFEHaptoglobinInflammationObesity

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