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Direct Metal- and Reagent-Free Sulfonylation of Phenols with Sodium Sulfinates by Electrosynthesis
Joachim Nikl1, Sebastian Lips1, Dieter Schollmeyer1
1Institut für Organische Chemie, Johannes Gutenberg-Universität Mainz, Duesbergweg 10-14, 55128, Mainz, Germany.
Abstract:
A novel electrochemical strategy for the synthesis of aryl sulfones by direct sulfonylation of phenols with sodium sulfinates has been developed. The C,S-coupling products are of particular interest for chemical synthesis, material sciences and pharmaceutical sciences. By using this metal- and reagent-free electrochemical method, aryl and diaryl sulfones can be obtained directly in good yields. The established one-step protocol is easy to perform, scalable, inherently safe, and enables a broad scope, which is not limited by quinoid-forming substrates.
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