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Electrochemical and Scalable Dehydrogenative C(sp3 )-H Amination via Remote Hydrogen Atom Transfer in Batch and
Pavlo Nikolaienko1, Marc Jentsch2, Ajit P Kale1
1KAUST Catalysis Center (KCC), King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Saudi Arabia.
Abstract:
A hydrogen atom transfer-directed electrochemical intramolecular C-H amination has been developed in which the N-radical species are generated at the anode, and the base required for the reaction is generated at the cathode. A broad range of valuable pyrrolidines were prepared in good yields and with high chemoselectivity. The reaction was easily scaled up in both batch and continuous flow systems.
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