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An Introduction to Worm Lab: from Culturing Worms to Mutagenesis
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Breaking Symmetry: Worm Cue Finally Found
Bruce Bowerman1, Kenji Sugioka2
1Institute of Molecular Biology, University of Oregon, Eugene, OR 97403, USA.
Developmental Cell
|March 13, 2019
Abstract:
In this issue of Developmental Cell, Zhao et al. (2019) show that the Aurora A kinase AIR-1 is the long-sought cue that downregulates cortical actomyosin to establish anterior-posterior polarity in the C. elegans zygote, diffusing from centrosomes to the overlying cortex to phosphorylate yet to be identified target(s).
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