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Related Concept Videos

Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

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Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
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Cognitive-behavioral therapies (CBTs) are grounded in the belief that our thoughts profoundly influence our emotions and actions. Advocates of CBT emphasize three core assumptions: first, that cognitions are identifiable and measurable; second, that they are central to psychological functioning; and third, that irrational or maladaptive beliefs can be replaced with rational and adaptive ones. This transformative approach to therapy has paved the way for specific models such as Albert...
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Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
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[Barrett-Screening: Rational, current concepts and perspectives].

Josef Weismüller1, René Thieme2, Albrecht Hoffmeister3

  • 1Gastroenterologische Praxis, Koblenz.

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|March 13, 2019
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Summary
This summary is machine-generated.

Esophageal adenocarcinoma (EAC) screening needs improvement due to poor prognosis and low detection rates with current endoscopy methods. Biomarker-based approaches, like the Cytosponge, show promise for effective population screening.

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Area of Science:

  • Gastroenterology and Oncology
  • Cancer Screening Technologies

Background:

  • Esophageal adenocarcinoma (EAC) incidence is rising, yet it remains uncommon with a poor prognosis.
  • Current screening relies on endoscopy for Barrett's esophagus (BE) and EAC, often in patients with GERD, but lacks effectiveness, missing most cases.

Purpose of the Study:

  • To explore the need for and potential of new screening methods for BE and EAC.
  • To identify promising biomarker-based techniques for population screening in primary care settings.

Main Methods:

  • Review of current endoscopy-based screening for BE/EAC.
  • Evaluation of emerging biomarker-based screening techniques.
  • Focus on cost-effective and practical methods for primary care.

Main Results:

  • Endoscopy is the gold standard but is expensive and detects only a minority of EAC cases.
  • Biomarker-based techniques are considered the most promising for population screening.
  • The Cytosponge combined with biomarkers demonstrated potential in clinical trials.

Conclusions:

  • New, effective screening strategies for BE and EAC are urgently needed.
  • Biomarker-based screening, particularly the Cytosponge, offers a promising, practical approach for wider population surveillance.