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Combination therapy for patients with Type 2 diabetes: repaglinide in combination with metformin

Robert G Moses1

  • 1a Clinical Trial and Research Unit, South Eastern Sydney and Illawarra Area Health Service, PO Box W58, Wollongong West, NSW, 2500, Australia. robert.moses@sesiahs.health.nsw.gov.au.

Expert Review of Endocrinology & Metabolism
|March 14, 2019
PubMed

Insights

Repaglinide and metformin combination therapy improves glycemic control in Type 2 diabetes mellitus (T2DM) when monotherapy is insufficient. This safe and effective treatment aids in managing blood glucose levels and reducing long-term complications.

Area of Science:

  • Endocrinology
  • Pharmacology
  • Metabolic Diseases

Background:

  • Type 2 diabetes mellitus (T2DM) management requires adequate glycemic control to prevent micro- and macro-vascular complications.
  • Traditional T2DM treatment involves monotherapy followed by combination therapy targeting key defects.
  • Insulin resistance and impaired insulin secretion are primary defects in T2DM.

Purpose of the Study:

  • To evaluate the efficacy and safety of repaglinide plus metformin combination therapy in T2DM patients.
  • To assess the role of this combination as an adjunct to diet and exercise.
  • To determine the effectiveness of this combination when oral antidiabetic monotherapy fails.

Main Methods:

  • Repaglinide, a mealtime insulin secretagogue, reduces postprandial glucose.
  • Metformin, an insulin sensitizer, addresses insulin resistance.
  • Combination therapy integrates these agents to target multiple T2DM defects.

Main Results:

  • Repaglinide and metformin combination therapy improves 24-hour glucose profiles and HbA1c levels.
  • This combination is safe and effective for T2DM patients.
  • It demonstrates significant benefits when monotherapy is inadequate.

Conclusions:

  • Combination therapy with repaglinide and metformin is a valuable treatment option for T2DM.
  • It effectively improves glycemic control in adults with T2DM.
  • This approach is indicated as an adjunct to diet and exercise for better T2DM management.
Keywords:
Type 2 diabetes mellitusbiguanidescombination therapyhyperglycemiainsulin secretioninsulin sensitivitymeglitinidemetforminrepaglinide

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