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GPCR photopharmacology

Maria Ricart-Ortega1, Joan Font2, Amadeu Llebaria3

  • 1MCS, Laboratory of Medicinal Chemistry, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Barcelona, Spain; IGF, CNRS, INSERM, University de Montpellier, F-34094, Montpellier, France.

Molecular and Cellular Endocrinology
|March 14, 2019
PubMed
Summary

New light-controlled drugs, known as photopharmacology, offer precise remote regulation of G protein-coupled receptors (GPCRs). This breakthrough advances understanding of receptor signaling and holds promise for novel light-operated medicines.

Keywords:
Caged compoundsG protein-coupled receptorsPhotochromic ligandsPhotopharmacologyPhotoswitchable orthogonal remotely tethered ligandsPhotoswitchable tethered ligands

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