Relationship between serum osteocalcin/undercarboxylated osteocalcin and type 2 diabetes: a systematic...

Area of Science:

• Endocrinology
• Metabolic Diseases
• Bone Biology

Background:

• Type 2 Diabetes Mellitus (T2DM) poses a growing global health challenge.
• Osteocalcin (OC), a bone-derived hormone, shows potential in improving beta-cell function and insulin sensitivity.
• The undercarboxylated form of osteocalcin (ucOC) is considered the active form influencing glucose metabolism, yet its role in T2DM requires further investigation.

Purpose of the Study:

• To systematically review and meta-analyze the association between serum osteocalcin (OC) and undercarboxylated osteocalcin (ucOC) levels and type 2 diabetes (T2DM).
• To evaluate the risk of T2DM associated with OC and ucOC levels.
• To explore the correlation of OC and ucOC with key metabolic parameters including insulin resistance and glycemic control.

Main Methods:

• A systematic review and meta-analysis of observational and intervention studies with baseline data.
• Searches of MEDLINE, EMBASE, and SCOPUS databases from inception to July 2018.
• Risk of bias assessment using the Newcastle-Ottawa Scale and heterogeneity testing via meta-regression and subgroup analyses.

Main Results:

• The study aims to compare serum OC and ucOC levels between T2DM patients, pre-diabetes (PD) individuals, and normal glucose-tolerant controls (NGC).
• It will investigate the risk ratios for T2DM associated with OC and ucOC.
• Correlations between OC/ucOC and fasting insulin, HOMA-IR, HbA1c, and fasting glucose will be determined.

Conclusions:

• This systematic review will provide a comprehensive analysis of the current evidence on osteocalcin and its undercarboxylated form in relation to type 2 diabetes.
• The findings are expected to elucidate the role of OC and ucOC in glucose metabolism and T2DM pathogenesis.
• Results will inform potential therapeutic strategies targeting osteocalcin for diabetes management.