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Genome Analysis of A Novel Recombinant Human Adenovirus Type 1 in China

Wanju Zhang1, Lisu Huang2

  • 1Shanghai Public Health Clinical Center, Fudan university, Shanghai, 201508, China. zhangwanju2010@163.com.

Scientific Reports
|March 14, 2019
PubMed

Insights

A novel human adenovirus type C (HAdV-C) strain, SH2016, was identified in an infant with severe acute respiratory infection. This finding highlights frequent recombination as a driver of HAdV-C diversity in Shanghai.

Area of Science:

  • Virology
  • Genomics
  • Infectious Diseases

Background:

  • Human adenovirus (HAdV) group C are common causes of severe acute respiratory infections (SARI) in infants.
  • Understanding the genetic diversity and evolution of HAdV-C is crucial for public health.

Purpose of the Study:

  • To characterize a novel recombinant HAdV-C strain (SH2016) isolated from an infant with SARI.
  • To investigate the role of recombination in the genetic polymorphism of HAdV-C in Shanghai.

Main Methods:

  • Whole-genome sequencing of the novel SH2016 strain.
  • Comparative genomic analysis with publicly available HAdV genomes.
  • Recombination detection (RDP) and phylogenetic analyses.

Main Results:

  • A novel recombinant HAdV-C strain, SH2016, was identified.
  • The SH2016 genome (35,946 nucleotides, 40 putative proteins) showed evidence of recombination with HAdV-1 and HAdV-2.
  • Frequent recombination appears to drive HAdV-C genetic diversity in Shanghai.

Conclusions:

  • The novel SH2016 strain represents a new subtype of HAdV-C.
  • Recombination is a significant factor in the evolution and polymorphism of HAdV-C in Shanghai.
  • Further surveillance and studies on pathogenicity are needed for this novel strain.

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