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Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo
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Investigating spontaneous retinal venous pulsation using Doppler optical coherence tomography
Andreas Wartak1, Florian Beer2, Sylvia Desissaire2
1Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, 1090, Austria. andreas.wartak@meduniwien.ac.at.
Scientific Reports
|March 14, 2019
Summary
Optical coherence tomography (OCT) offers superior imaging for spontaneous retinal venous pulsation (SRVP) analysis. This study presents the first quantitative, time-resolved investigation of SRVP using OCT and Doppler OCT.
Area of Science:
- Ophthalmology
- Medical Imaging
- Biomedical Engineering
Background:
- Spontaneous retinal venous pulsation (SRVP) is a visible sign of ocular hemodynamics.
- Current evaluation of SRVP often relies on standard en-face imaging like scanning laser ophthalmoscopy (SLO).
- Limitations exist in conventional methods for detailed, quantitative analysis of venous pulsatility.
Purpose of the Study:
- To demonstrate the advantages of optical coherence tomography (OCT) for investigating SRVP.
- To quantitatively analyze pulsatile changes in retinal venous caliber and flow using OCT and Doppler OCT (DOCT).
- To compare OCT-based SRVP assessment with traditional SLO methods.
Main Methods:
- Utilized multi-channel OCT prototype with single-channel and double-channel line scanning protocols.
- Employed conventional intensity-based OCT and functional Doppler OCT (DOCT) for analysis.
- Investigated venous pulsatile caliber oscillations and venous flow pulsatility in healthy volunteers.
- Compared OCT findings with scanning laser ophthalmoscopy (SLO) recordings.
Main Results:
- OCT provides tomographic imaging, offering advantages over en-face SLO for SRVP evaluation.
- Quantitative, time-resolved analysis of SRVP and retinal perfusion characteristics was achieved using OCT and DOCT.
- Demonstrated the capability of OCT to assess both venous caliber oscillations and flow pulsatility.
Conclusions:
- Optical coherence tomography (OCT) is a powerful tool for detailed investigation of spontaneous retinal venous pulsation (SRVP).
- Doppler OCT (DOCT) enables quantitative, time-resolved assessment of retinal venous pulsatility and perfusion.
- OCT imaging offers significant advantages over SLO for comprehensive SRVP analysis.
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