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Related Concept Videos

Functions of the Lymphatic and Immune System01:28

Functions of the Lymphatic and Immune System

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The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
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Immunity is a crucial biological concept about our body's inherent capacity to prevent infections and diseases. A complex network of cells and tissues collectively known as the immune system facilitates this natural defense mechanism. The immune system plays an integral role in maintaining our health and well-being, shielding us from potential health threats.
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Functional groups are a group of atoms with characteristic properties, which when linked to the carbon skeleton of a molecule, alter the properties of that molecule. For example, the presence of certain functional groups on a molecule will make them hydrophilic, whereas others will make them hydrophobic. These functional groups are an indispensable part of organic chemistry and important components of biological molecules, such as carbohydrates, proteins, lipids, and nucleic acids. Each...
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Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice
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Inflammation and Lymphatic Function.

Simon Schwager1, Michael Detmar1

  • 1Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland.

Frontiers in Immunology
|March 14, 2019
PubMed
Summary

Stimulating lymphatic vessels, particularly with vascular endothelial growth factor C (VEGF-C), can reduce inflammation. Enhancing lymphatic function improves drainage and offers a promising therapeutic strategy for inflammatory diseases.

Keywords:
arthritisinflammationinflammatory bowel diseaseinflammatory mediatorslymphangiogenesislymphatic vesselspsoriasisskin

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Area of Science:

  • Immunology
  • Vascular Biology
  • Pathophysiology

Background:

  • The lymphatic vasculature is critical for managing inflammatory responses through fluid and cell drainage.
  • Inflammation leads to lymphatic vessel enlargement and dysfunction, impairing drainage capabilities.
  • Dysfunctional lymphatic vessels exacerbate inflammatory conditions like inflammatory bowel disease (IBD) and rheumatoid arthritis.

Purpose of the Study:

  • To investigate the role of lymphatic vasculature in regulating inflammation.
  • To explore the therapeutic potential of modulating lymphatic function in inflammatory diseases.
  • To assess the impact of vascular endothelial growth factor C (VEGF-C)/vascular endothelial growth factor receptor 3 (VEGFR-3) signaling on lymphatic vessel function during inflammation.

Main Methods:

  • Interfering with VEGF-C/VEGFR-3 signaling to observe effects on inflammation.
  • Stimulating lymphatic vasculature via genetic or viral overexpression and local VEGF-C injections.
  • Assessing lymphatic function through drainage of dyes, tracers, and inflammatory cells.
  • Analyzing the influence of inflammatory mediators (TNF-α, IL-1β, nitric oxide) on lymphatic drainage.

Main Results:

  • Blocking VEGF-C/VEGFR-3 signaling exacerbates inflammation in various disease models.
  • Stimulation of lymphatic vasculature reduces inflammation severity in models of rheumatoid arthritis, skin inflammation, and IBD.
  • Induced lymphatic expansion improves lymphatic function, enhancing the drainage of inflammatory components.

Conclusions:

  • Lymphatic vessel function is a key determinant of inflammatory response severity.
  • Targeted administration of pro-lymphangiogenic factors, such as VEGF-C, represents a promising therapeutic strategy for inflammatory pathologies.
  • Enhancing lymphatic drainage through VEGF-C/VEGFR-3 signaling modulation can mitigate inflammatory conditions.