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Gene-Environment Interactions01:20

Gene-Environment Interactions

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Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
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Background and Environment Affect Phenotype02:27

Background and Environment Affect Phenotype

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Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
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Plasticizers01:31

Plasticizers

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Water-reducers, or plasticizers, are chemical admixtures used in concrete to improve strength and workability. These additives reduce the water-cement ratio without compromising workability, lower the cement content while maintaining the same workability, or increase workability to assist concrete placement in inaccessible areas.
Plasticizers function by using surface-active agents to create repulsive electrostatic forces between cement particles. This dispersion enhances the concrete's...
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Plasticity00:58

Plasticity

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Plasticity is the property where an object loses its elasticity and undergoes irreversible deformation, even after the deformation forces are eliminated. If a material deforms irreversibly without increasing stress or load, then this is called ideal plasticity. For example, when a force is applied to an aluminum rod, it changes its shape, but it does not return to its original shape once the force is removed. Plastic deformation or ductility is thus a permanent deformation or change in the...
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Plastic Behavior01:21

Plastic Behavior

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A material's elastic behavior is characterized by the disappearance of stress once the load is removed, allowing the material to return to its original state. However, when stress surpasses the yield point, yielding commences, marking the onset of plastic deformation or permanent set. This change from elastic to plastic behavior is influenced by the peak stress value and the duration before the load is removed. An intriguing observation occurs when a specimen is loaded, unloaded, and...
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Plastic Deformations01:14

Plastic Deformations

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It is essential to understand how structural members behave under plastic deformation when the bending stress exceeds the material's yield strength. This state of deformation permanently alters the shape of the member, in contrast to the linear elastic behavior observed before yielding. The strain at any point in the member is expressed in terms of maximum strain. Notably, the neutral axis, which coincides with the centroid during elastic bending, shifts away from the centroid under plastic...
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Related Experiment Video

Updated: Jan 27, 2026

A Telemetric, Gravimetric Platform for Real-Time Physiological Phenotyping of Plant–Environment Interactions
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A Telemetric, Gravimetric Platform for Real-Time Physiological Phenotyping of Plant–Environment Interactions

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Polyphenism - A Window Into Gene-Environment Interactions and Phenotypic Plasticity.

Chih-Hsiang Yang1,2, John Andrew Pospisilik1,2

  • 1Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.

Frontiers in Genetics
|March 14, 2019
PubMed
Summary

Polyphenisms, where one genotype produces distinct phenotypes, are widespread in animals. Epigenetic regulation drives these stable differences, and humans may exhibit subtle metabolic polyphenisms.

Keywords:
environmentepigenomemetabolismobesitypolyphenism

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Area of Science:

  • Evolutionary biology
  • Developmental biology
  • Genetics

Background:

  • Phenotypic plasticity allows genotypes to produce varied phenotypes.
  • Polyphenism is a form of phenotypic plasticity with discrete, stable phenotypes.
  • Epigenetic regulation is key to polyphenism and its evolutionary basis.

Purpose of the Study:

  • To summarize the diversity and ubiquity of polyphenisms across the animal kingdom.
  • To review well-characterized models of polyphenism across taxa.
  • To explore potential human metabolic polyphenisms.

Main Methods:

  • Literature review of polyphenism across diverse animal taxa.
  • Analysis of epidemiological patterns in polyphenism.
  • Examination of molecular mechanisms underlying polyphenism.
  • Review of evidence for human metabolic polyphenism.

Main Results:

  • Polyphenisms are broadly distributed and diverse throughout the animal kingdom.
  • Consistent themes in epidemiology and molecular mechanisms are observed across studied models.
  • Evidence suggests a potential for subtle metabolic polyphenisms in humans.

Conclusions:

  • Polyphenism is a significant evolutionary and developmental phenomenon.
  • Epigenetic mechanisms are crucial for generating and maintaining discrete phenotypes.
  • Further research is warranted to understand human metabolic polyphenisms.