Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lung Capacity01:47

Lung Capacity

56.2K
The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
56.2K
Pleura of the Lungs01:13

Pleura of the Lungs

7.0K
The lungs are nestled in a cavity, shielded by the pleura. The pleura, a form of serous membrane, wraps around each lung. This membrane arrangement consists of two layers: the visceral and parietal pleurae. The visceral pleura lines the surface of the lungIn contrast, the parietal pleura is the outer layer and contacts to the thoracic wall, the mediastinum, and the diaphragm. The hilum is the point of connection between the visceral and parietal layers. The space between the parietal and...
7.0K
Gross Anatomy of the Lungs01:17

Gross Anatomy of the Lungs

4.6K
The lungs are a pair of vital organs connected to the trachea via the left and right bronchi. The base of these organs meets the dome-shaped muscle known as the diaphragm. Encased by the pleurae, the lungs contact the mediastinum. The right lung is shorter yet wider, and has a larger volume than the left lung. The left lung has an indentation known as the cardiac notch. The superior region of the lungs is referred to as the apex, whereas the base is the lower region near the diaphragm. The...
4.6K
Cancer02:18

Cancer

54.2K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
54.2K
What is Cancer?02:12

What is Cancer?

14.4K
Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
14.4K
Cancer Vaccines01:30

Cancer Vaccines

1.0K
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
1.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Obesity Promotes Lung Carcinogenesis Through Airway Immune Dysfunction.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer·2026
Same author

Representing dental caries and dysbiosis within the oral microbiome in the Oral Health and Disease Ontology.

Journal of biomedical semantics·2026
Same author

Microbiome analysis of 940 lung cancers in never-smokers reveals lack of clinically relevant associations.

Nature communications·2025
Same author

Amylase Binding to Oral Streptococci: A Key Interaction for Human Oral Microbial Ecology, Adaptation and Fitness.

Biomolecules·2025
Same author

The Neurosurgical Management of Pancoast Tumors: Neurological Function and Survival Outcomes With a Brachial Plexus Preserving Operative Technique.

Neurosurgery practice·2025
Same author

Long-term outcomes from pembrolizumab monotherapy in patients with advanced NSCLC, PD-L1 expression ≥ 50 %, and poor performance status: Transformer-based AI to characterize prognostic complexity.

Lung cancer (Amsterdam, Netherlands)·2025

Related Experiment Video

Updated: Jan 27, 2026

Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing
05:17

Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing

Published on: October 10, 2025

379

The microbiome and lung cancer.

Abhiram Maddi1, Amarpreet Sabharwal1, Timothy Violante1

  • 1Department of Periodontics & Endodontics, School of Dental Medicine, State University of New York, Buffalo, NY, USA.

Journal of Thoracic Disease
|March 14, 2019
PubMed
Summary

The human microbiome, particularly oral and lung microbes, plays a significant role in lung cancer development. Understanding these microbial communities and their link to cancer is crucial for future diagnostics and treatments.

Keywords:
Microbiomecarcinogenesislung cancer

More Related Videos

Instillation and Fixation Methods Useful in Mouse Lung Cancer Research
06:57

Instillation and Fixation Methods Useful in Mouse Lung Cancer Research

Published on: August 31, 2015

29.5K
A Permanent Window for Investigating Cancer Metastasis to the Lung
07:06

A Permanent Window for Investigating Cancer Metastasis to the Lung

Published on: July 1, 2021

5.5K

Related Experiment Videos

Last Updated: Jan 27, 2026

Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing
05:17

Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing

Published on: October 10, 2025

379
Instillation and Fixation Methods Useful in Mouse Lung Cancer Research
06:57

Instillation and Fixation Methods Useful in Mouse Lung Cancer Research

Published on: August 31, 2015

29.5K
A Permanent Window for Investigating Cancer Metastasis to the Lung
07:06

A Permanent Window for Investigating Cancer Metastasis to the Lung

Published on: July 1, 2021

5.5K

Area of Science:

  • Microbiology and Oncology
  • Human Microbiome Research

Background:

  • The human body hosts a complex microbiome essential for physiology and implicated in pathology.
  • Microorganisms' carcinogenic potential is increasingly recognized, with the microbiome's role in cancer development being a rapidly evolving field.
  • Omics technologies are revolutionizing the study of the microbiome.

Purpose of the Study:

  • To review the current understanding of the microbiome's role in human lung cancer.
  • To highlight the specific contributions of the oral and lung microbiomes to lung carcinogenesis.
  • To provide context on the microbiome's general role in cancer and introduce relevant technologies.

Main Methods:

  • Review of existing scientific literature on the microbiome and lung cancer.
  • Analysis of studies utilizing omics technologies for microbiome cataloging.
  • Synthesis of evidence linking oral and lung microbiomes to lung cancer development.

Main Results:

  • The lung harbors a distinct microbiome that influences lung cancer development.
  • Evidence suggests the lung microbiome originates from the oral microbiome.
  • The microbiome's role in carcinogenesis is significant and may have been underestimated.

Conclusions:

  • The oral and lung microbiomes are critical factors in human lung cancer.
  • Further research into the microbiome-lung cancer axis is warranted.
  • Understanding microbiome analysis technologies is essential for clinicians.