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Preparation and Characterization of Novel HDL-mimicking Nanoparticles for Nerve Growth Factor Encapsulation
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HDL Subclass Distribution Shifts with Increasing Central Adiposity.

Nicholas J Woudberg1, Sandrine Lecour1, Julia H Goedecke2,3

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In black South African women, increased body fat and a shift towards central fat distribution over 5.5 years were linked to a decrease in large high-density lipoprotein (HDL) subclasses. This suggests a connection between body fat changes and HDL particle size.

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Area of Science:

  • Lipidology
  • Body Composition
  • Metabolic Health

Background:

  • Cross-sectional studies indicate obesity is linked to lower concentrations of large high-density lipoprotein (HDL) subclasses.
  • Longitudinal data on the relationship between changes in body fat distribution and HDL subclass dynamics are lacking.

Purpose of the Study:

  • To investigate the association between changes in body fat and its distribution and alterations in HDL subclass profiles over time.
  • To explore the relationship between body fat redistribution and HDL subclass size in black South African women.

Main Methods:

  • A 5.5-year prospective study involving 24 black South African women.
  • Assessment of body composition and fat distribution using anthropometry, dual X-ray absorptiometry, and computerized tomography.
  • Quantification of HDL subclass distribution using Lipoprint® technology.

Main Results:

  • Significant increases in overall body fat and central (trunk) fat mass were observed over the follow-up period.
  • A decrease in peripheral (leg) fat mass and a reduction in large HDL subclasses were noted.
  • Decreased large HDL subclasses correlated with increased visceral adipose tissue (VAT) area and decreased leg fat mass.

Conclusions:

  • A relative redistribution of body fat from the periphery to the abdominal region is associated with a decrease in large HDL subclasses in this cohort.
  • These findings establish a novel link between longitudinal changes in body fat distribution and lipid profiles, specifically HDL subclasses, in black South African women.