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Patiromer Acetate Induced Hypercalcemia: An Unreported Adverse Effect
Shreeyukta Bhattarai1,2, Stephen Pupillo1,2, Gulshan Man Singh Dangol1,2
1Northeast Ohio Medical University, Department of Medicine, Rootstown, Ohio, USA.
Case Reports in Nephrology
|March 14, 2019
Summary
Patiromer acetate, used for hyperkalemia in chronic kidney disease (CKD), may cause hypercalcemia. This case report highlights a potential risk clinicians should monitor in CKD patients using this treatment.
Area of Science:
- Nephrology
- Pharmacology
Background:
- Hyperkalemia is a common and serious complication in patients with chronic kidney disease (CKD).
- Patiromer acetate is a potassium binder used for managing persistent hyperkalemia in CKD.
- Gastrointestinal side effects are the most frequently reported adverse events associated with patiromer therapy.
Observation:
- Hypercalcemia is a theoretical but previously unreported side effect of patiromer acetate.
- This report details a case of hypercalcemia in a stage IV CKD patient undergoing treatment for hyperkalemia with patiromer.
Findings:
- The patient developed hypercalcemia while receiving patiromer acetate for hyperkalemia management.
- This finding suggests a potential link between patiromer acetate and the development of hypercalcemia, contrary to previous clinical trial observations.
Implications:
- Clinicians should exercise caution and consider monitoring for hypercalcemia in CKD patients treated with patiromer acetate.
- This case underscores the importance of vigilance for rare or previously undocumented adverse effects of medications in specific patient populations.
- Further investigation may be warranted to understand the mechanism and incidence of patiromer-associated hypercalcemia.
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