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Concomitant paraganglioma and thyroid carcinoma: A case report
Bo Lin1, Hong-Yu Yang2, Hui-Jun Yang1
1Department of Oral and Maxillofacial Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, Guangdong Province, China.
World Journal of Clinical Cases
|March 14, 2019
Summary
This study reports a rare case of head and neck paraganglioma co-occurring with papillary thyroid carcinoma in a 51-year-old man. The association may be coincidental or linked to an unidentified genetic mutation.
Area of Science:
- Endocrinology
- Oncology
- Head and Neck Surgery
Background:
- Paragangliomas and medullary thyroid carcinoma are associated with Multiple Endocrine Neoplasia (MEN).
- Papillary thyroid carcinoma is rarely associated with paraganglioma.
- This case highlights a rare co-occurrence of head and neck paraganglioma and papillary thyroid carcinoma.
Observation:
- A 51-year-old male presented with right neck swelling and hypertension.
- Physical examination revealed pulsatile neck masses.
- Imaging identified a carotid artery bifurcation tumor and a thyroid isthmus nodule.
Findings:
- Fine needle aspiration biopsy confirmed papillary thyroid carcinoma in the thyroid nodule.
- Surgical resection revealed both paraganglioma and papillary carcinoma.
- Genetic analysis for succinate dehydrogenase subunit D germline mutation was negative.
Implications:
- The co-occurrence of paraganglioma and papillary thyroid carcinoma may be coincidental.
- An unknown genetic mutation could underlie this rare association.
- Further research is needed to elucidate the potential mechanisms linking these two neoplasms.
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