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Updated: Jan 27, 2026

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Regional differences in mitral cell development in mouse olfactory bulb.

Uyen P Nguyen1, Fumiaki Imamura1

  • 1Department of Pharmacology, Penn State College of Medicine, Hershey, Pennsylvania.

The Journal of Comparative Neurology
|March 14, 2019
PubMed
Summary
This summary is machine-generated.

Olfactory bulb development shows regional differences in projection neuron development, with Tbx21 expression appearing sequentially in specific areas. This suggests a correlation between olfactory sensory neuron generation and target region maturation.

Keywords:
RRID:AB_141514RRID:AB_141596RRID:AB_141708RRID:AB_141709RRID:AB_141788RRID:AB_142672RRID:AB_1603148RRID:AB_162543RRID:AB_2149710RRID:AB_2200219RRID:AB_2209751RRID:AB_2315007RRID:AB_2629482RRID:AB_400326RRID:AB_609568RRID:AB_778267RRID:AB_887877RRID:IMSR_CRL:22RRID:IMSR_JAX:007909RRID:IMSR_JAX:024507RRID:SCR_014199compartmentdevelopmentmitral cellolfactory bulbtongue-shaped area

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Olfactory System Research

Background:

  • Olfactory sensory neurons (OSNs) in the olfactory epithelium (OE) exhibit regional molecular differences.
  • These differences correlate with segregated regions in the olfactory bulb (OB) glomerular layer.
  • Complementary regional organization in OB projection neurons remains largely uncharacterized.

Purpose of the Study:

  • To investigate the developmental compartmentalization of projection neurons in the olfactory bulb.
  • To compare the developmental timelines of different OB regions.
  • To explore the role of transcription factor Tbx21 in OB development.

Main Methods:

  • Analysis of Tbx21 expression in the developing OB across various developmental ages.
  • Mapping of OSN innervation patterns from specific OE regions to OB targets.
  • Comparison of developmental expression patterns of Tbx21 and vGluT1 in the OB.

Main Results:

  • Tbx21 expression initiates in the anteromedial OB (tongue-shaped area), followed by dorsomedial, then ventrolateral regions.
  • The tongue-shaped area is innervated by OSNs from the dorsomedial ventrolateral OE (V-zone:DM).
  • OSN generation timing in the OE correlates with Tbx21 expression onset in their OB target regions.
  • vGluT1 expression in the OB first appears in the ventrolateral region during development.

Conclusions:

  • Olfactory bulb projection neuron development is compartmentalized into distinct regions (tongue-shaped, dorsomedial, ventrolateral).
  • Developmental pathways for OB projection neurons are not uniform.
  • The timing of OSN generation in the OE may influence the developmental trajectory of their target OB regions.