Posaconazole salvage therapy: The Posifi study.

Area of Science:

• Mycology
• Infectious Diseases
• Pharmacology

Background:

• Posaconazole (PCZ) is primarily used for preventing invasive fungal infections (IFI).
• This study investigates PCZ's efficacy in treating established IFI.
• Focuses on non-prophylactic applications of PCZ.

Purpose of the Study:

• To evaluate the use of Posaconazole (PCZ) in the treatment of invasive fungal infections (IFI).
• To assess different administration forms of PCZ for IFI treatment.
• To determine the effectiveness and safety of PCZ as salvage therapy.

Main Methods:

• Multicentre retrospective, non-randomized, single-arm study.
• Involved 67 patients across six tertiary hospitals in Spain.
• Evaluated PCZ in various forms for treating IFI.

Main Results:

• Posaconazole was used as salvage therapy in 97% of cases.
• Effective against Aspergillosis, Zygomycosis, other moulds, and yeast.
• Oral solution linked to low serum levels in 63%; low toxicity observed.

Conclusions:

• Posaconazole salvage therapy is a viable option for IFI patients.
• Oral tablets demonstrate effectiveness for refractory or intolerant cases.
• PCZ offers an alternative for difficult-to-treat invasive fungal infections.