Synthesis, Docking Studies into CDK-2 and Anticancer Activity of New Derivatives Based Pyrimidine Scaffold and Their

Adel A H Abdel Rahman1, Ibrahim F Nassar2, Amira K F Shaban1

  • 1Chemistry Department, Faculty of Science, Menofia University, Shebin El-Kom, Egypt.

Abstract

Related Concept Videos

Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
6.0K
Measurement: Derived Units03:02

Measurement: Derived Units

The International System of Units or SI system, by international agreement, has fixed measurement units for seven fundamental properties: length, mass, time, temperature, electric current, amount of substance, and luminosity. These are called the SI base units.
55.1K
Base Quantities and Derived Quantities01:14

Base Quantities and Derived Quantities

In any system of units, the units for some physical quantities must be specified through a measurement process. These measurements are the base quantities of the system, and their units are the base units of the system. The algebraic combinations of the base values can then be used to express all other physical quantities. Each of these physical quantities is then referred to as a derived quantity, with each unit being referred to as a derived unit.
The International Organization for...
26.0K
Loss of Carboxy Group as CO2: Decarboxylation of Malonic Acid Derivatives01:35

Loss of Carboxy Group as CO2: Decarboxylation of Malonic Acid Derivatives

Just like β-keto acids—which upon thermal decarboxylation form ketones—β-dicarboxylic acids undergo decarboxylation to generate monocarboxylic acids with the liberation of carbon dioxide.
2.6K
First Derivative Test: Problem Solving01:25

First Derivative Test: Problem Solving

Imagine an asset price that crashes to a low point, rebounds sharply as bargain-hunters step in, and then gradually declines. Such behavior can be modeled with a smooth function whose turning points represent locally overvalued and undervalued regions. A convenient example that captures rebound followed by decay is:The high and low points of this curve are identified using the first derivative test, which determines where the function changes from increasing to decreasing or vice versa. To...
61
Second Derivative Test: Problem Solving01:24

Second Derivative Test: Problem Solving

In mathematical analysis, finding a function's highest and lowest points is crucial for understanding its behavior. These points, known as critical points, occur where the first derivative is either zero or undefined. Critical points are potential local maxima and minima locations, which can be classified using the Second Derivative Test. However, not every critical point corresponds to a local maximum or minimum. The second derivative is analyzed to classify these points. The second derivative...
87