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Does the Bethesda category predict aggressive features in differentiated thyroid cancer?
Ana Rafaela Lopes Reis Lima1, Karoline Matias Morais de Medeiros1, Conceição de Maria Ribeiro Veiga Parente1
1Serviço de Endocrinologia do Hospital Universitário da Universidade Federal do Maranhão (UFMA), São Luís, MA, Brasil.
Archives of Endocrinology and Metabolism
|March 14, 2019
Summary
Preoperative fine-needle aspiration (FNA) cytology for thyroid nodules is crucial. It correlates with extrathyroidal extension, vascular invasion, and lymph node metastasis in differentiated thyroid carcinoma patients.
Area of Science:
- Endocrinology
- Oncology
- Pathology
Background:
- Differentiated thyroid carcinoma (DTC) is the most common endocrine malignancy.
- Accurate preoperative assessment of thyroid nodules is essential for effective patient management and prognosis.
Purpose of the Study:
- To evaluate the significance of preoperative thyroid nodule cytology.
- To determine its association with mortality risk, recurrence, and aggressive tumor characteristics in DTC.
Main Methods:
- Retrospective analysis of 153 patients with DTC.
- Data collected from January 1999 to December 2016.
- Inclusion of fine-needle aspiration (FNA) results and clinicopathological data.
Main Results:
- A significant correlation was found between preoperative FNA findings and extrathyroidal extension, vascular invasion, and lymph node metastasis.
- The majority of patients (85%) showed no evidence of disease progression.
- Female patients constituted 96% of the study cohort, with papillary carcinoma being the predominant subtype (79.7%).
Conclusions:
- Preoperative cytology of thyroid nodules plays a role in the follow-up management of DTC patients.
- Further research with larger cohorts is needed to validate these findings and their clinical implications.
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