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Related Concept Videos

Termination of Translation01:44

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The large ribosomal subunit has several important structures essential to translation. These include the peptidyl transferase center (PTC) - which is the site where the peptide bond is formed - and a large, internal, water-filled tube through which the nascent polypeptide moves. This latter structure is called the Peptide Exit Tunnel, and it begins at the PTC and spans the body of the large ribosomal subunit. During translation, as the nascent polypeptide chain is synthesized, it passes through...
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Bleeding in Fresh Concrete01:22

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Drag Force and Terminal Speed01:18

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An interesting force in everyday life is the force of drag on an object when it is moving in a fluid. Like friction, the drag force always opposes the motion of an object. Unlike simple friction, the drag force is proportional to some function of the velocity of the object in that fluid. This functionality is complicated and depends upon the shape of the object, its size, its velocity, and the fluid it is in. For most large objects, such as cyclists, cars, and baseballs, that are not moving too...
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Riboswitches01:56

Riboswitches

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Riboswitches are non-coding mRNA domains that regulate the transcription and translation of downstream genes without the help of proteins. Riboswitches bind directly to a metabolite and can form unique stem-loop or hairpin structures in response to the amount of the metabolite present. They have two distinct regions – a metabolite-binding aptamer and an expression platform.
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Transcription Attenuation in Prokaryotes02:42

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Transcriptional attenuation occurs when RNA transcription is prematurely terminated due to the formation of a terminator mRNA hairpin structure.  Bacteria use these hairpins to regulate the transcription process and control the synthesis of several amino acids including histidine, lysine, threonine, and phenylalanine. Transcription attenuation takes place in the non-coding regions of mRNA.
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Related Experiment Video

Updated: Jan 27, 2026

Tail Vein Transection Bleeding Model in Fully Anesthetized Hemophilia A Mice
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Terminal Bleeding in Angiosarcoma.

Jaya M Gill1, Brian Madden2, Janice Frost3

  • 11Department of Translational Neurosciences and Neurotherapeutics, Pacific Neuroscience Institute and John Wayne Cancer Institute at Providence Saint John's Health Center, Santa Monica, California.

Journal of Palliative Medicine
|March 14, 2019
PubMed
Summary

Terminal bleeding, a rare event in palliative care, can be fatal even without large volume loss. This case highlights challenges in managing bleeding in elderly patients with advanced angiosarcoma.

Keywords:
angiosarcomableedingcomplicationsmanagement

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Area of Science:

  • Palliative Care
  • Oncology
  • Vascular Neoplasms

Background:

  • Terminal bleeding is a distressing symptom in palliative care, often perceived as a catastrophic event.
  • It can manifest as prolonged bleeding, ultimately precipitating death.
  • Angiosarcoma is a rare, aggressive vascular neoplasm.

Observation:

  • A case of terminal bleeding in an 87-year-old patient with advanced angiosarcoma is presented.
  • The patient's advanced age and aggressive disease complicated symptom management.
  • Conventional bleeding interventions were precluded due to the patient's condition.

Findings:

  • Terminal bleeding can occur in advanced angiosarcoma, posing significant management challenges.
  • Multidisciplinary care is crucial for addressing complex bleeding scenarios in elderly cancer patients.
  • Prognosis, performance status, prior treatments, and patient preferences are key considerations.

Implications:

  • This case underscores the need for individualized, multidisciplinary care planning for patients with advanced cancer experiencing terminal bleeding.
  • It emphasizes adapting management strategies beyond conventional interventions based on patient-specific factors.
  • Improved understanding of terminal bleeding in rare cancers like angiosarcoma is vital for enhancing palliative care.